New concepts in acute‐on‐chronic liver failure: Implications for liver transplantation

Antonella Putignano, Thierry Gustot – 17 October 2016 – Acute‐on‐chronic liver failure (ACLF) is a recently defined syndrome that occurs frequently in patients with cirrhosis and is associated with a poor short‐term prognosis. Currently, management of patients with ACLF is mainly supportive. Despite medical progress, this syndrome frequently leads to multiorgan failure, sepsis, and, ultimately, death. The results of attempts to use liver transplantation (LT) to manage this critical condition have been poorly reported but are promising.

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