New concepts in acute‐on‐chronic liver failure: Implications for liver transplantation

Antonella Putignano, Thierry Gustot – 17 October 2016 – Acute‐on‐chronic liver failure (ACLF) is a recently defined syndrome that occurs frequently in patients with cirrhosis and is associated with a poor short‐term prognosis. Currently, management of patients with ACLF is mainly supportive. Despite medical progress, this syndrome frequently leads to multiorgan failure, sepsis, and, ultimately, death. The results of attempts to use liver transplantation (LT) to manage this critical condition have been poorly reported but are promising.

Living donor liver transplantation in patients weighing ≥100 kg: Low graft weight and obesity do not impact outcomes

Shaleen Agarwal, Neerav Goyal, Mohammed Nayeem, Shishir Pareek, Subash Gupta – 12 October 2016 – Living donor liver transplantation (LDLT) in obese patients raises concerns with regards to obtaining grafts of “adequate” graft‐to‐recipient weight ratio (GRWR) and the impact of obesity on the outcomes of LDLT. LDLT outcomes in patients weighing ≥100 kg were compared with those weighing <100 kg. Patients weighing ≥100 kg were divided into 3 categories based on the GRWR of the grafts they received.

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