Time trends in the health care burden and mortality of acute on chronic liver failure in the United States

Alina M. Allen, W. Ray Kim, James P. Moriarty, Nilay D. Shah, Joseph J. Larson, Patrick S. Kamath – 3 October 2016 – Acute on chronic liver failure (ACLF) is associated with multisystem organ failure and poor prognosis in hospitalized patients with cirrhosis. We aimed to determine time trends in the epidemiology, economic burden, and mortality of ACLF in the United States. The National Inpatient Sample database was queried between 2001 and 2011. ACLF was defined as two or more extrahepatic organ failures in patients with cirrhosis.

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