Donor safety in living donor liver donation: An Italian multicenter survey

Andrea Lauterio, Stefano Di Sandro, Salvatore Gruttadauria, Marco Spada, Fabrizio Di Benedetto, Umberto Baccarani, Enrico Regalia, Ernesto Melada, Alessandro Giacomoni, Matteo Cescon, Davide Cintorino, Giorgio Ercolani, Matteo Rota, Giorgio Rossi, Vincenzo Mazzaferro, Andrea Risaliti, Antonio Daniele Pinna, Bruno Gridelli, Luciano De Carlis – 6 October 2016 – Major concerns about donor morbidity and mortality still limit the use of living donor liver transplantation (LDLT) to overcome the organ shortage.

De novo autoimmune hepatitis after liver transplantation: A focus on glutathione S‐transferase theta 1

Luis Ibáñez‐Samaniego, Magdalena Salcedo, Javier Vaquero, Rafael Bañares – 6 October 2016 – De novo autoimmune hepatitis (DAIH) is a rare clinical condition with features that resemble those of autoimmune hepatitis (AIH) in patients undergoing liver transplantation (LT) for nonautoimmune liver disease. The diagnosis of this entity has been based on the presence of biochemical and histological patterns similar to those observed in the primary AIH, although several considerations must be taken into account.

Benefits of temporary portocaval shunt during orthotopic liver transplantation with vena cava preservation: A propensity score analysis

Michel Rayar, Giovanni B. Levi Sandri, Caterina Cusumano, Clara Locher, Pauline Houssel‐Debry, Christophe Camus, Nicolas Lombard, Veronique Desfourneaux, Mohamed Lakehal, Bernard Meunier, Laurent Sulpice, Karim Boudjema – 5 October 2016 – During orthotopic liver transplantation (OLT), clamping of the portal vein induces splanchnic venous congestion and accumulation of noxious compounds. These adverse effects could increase ischemia/reperfusion injury and subsequently the risk of graft dysfunction, especially for grafts harvested from extended criteria donors (ECDs).

Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood

Martin L. Decaris, Kelvin W. Li, Claire L. Emson, Michelle Gatmaitan, Shanshan Liu, Yenny Wang, Edna Nyangau, Marc Colangelo, Thomas E. Angel, Carine Beysen, Jeffrey Cui, Carolyn Hernandez, Len Lazaro, David A. Brenner, Scott M. Turner, Marc K. Hellerstein, Rohit Loomba – 5 October 2016 – Excess collagen synthesis (fibrogenesis) in the liver plays a causal role in the progression of nonalcoholic fatty liver disease (NAFLD). Methods are needed to identify patients with more rapidly progressing disease and to demonstrate early response to treatment.

Global lessons in graft type and pediatric liver allocation: A path toward improving outcomes and eliminating wait‐list mortality

Evelyn K. Hsu, George V. Mazariegos – 5 October 2016 – Current literature and policy in pediatric liver allocation and organ procurement are reviewed here in narrative fashion, highlighting historical context, ethical framework, technical/procurement considerations, and support for a logical way forward to an equitable pediatric liver allocation system that will improve pediatric wait‐list and posttransplant outcomes without adversely affecting adults.

Time trends in the health care burden and mortality of acute on chronic liver failure in the United States

Alina M. Allen, W. Ray Kim, James P. Moriarty, Nilay D. Shah, Joseph J. Larson, Patrick S. Kamath – 3 October 2016 – Acute on chronic liver failure (ACLF) is associated with multisystem organ failure and poor prognosis in hospitalized patients with cirrhosis. We aimed to determine time trends in the epidemiology, economic burden, and mortality of ACLF in the United States. The National Inpatient Sample database was queried between 2001 and 2011. ACLF was defined as two or more extrahepatic organ failures in patients with cirrhosis.

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