Anti‐inflammatory signaling during ex vivo liver perfusion improves the preservation of pig liver grafts before transplantation

Nicolas Goldaracena, Juan Echeverri, Vinzent N. Spetzler, Johan M. Kaths, Andrew S. Barbas, Kristine S. Louis, Oyedele A. Adeyi, David R. Grant, Nazia Selzner, Markus Selzner – 24 August 2016 – Normothermic ex vivo liver perfusion (NEVLP) improves graft preservation by avoiding cold ischemia injury. We investigated whether the protective effects of NEVLP can be further improved by applying strategies targeted on reducing the activation of proinflammatory cytokines during perfusion. Livers retrieved under heart‐beating conditions were perfused for 4 hours.

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

Zobair M. Younossi, Deirdre Blissett, Robert Blissett, Linda Henry, Maria Stepanova, Youssef Younossi, Andrei Racila, Sharon Hunt, Rachel Beckerman – 20 August 2016 – Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease. There is uncertainty around the economic burden of NAFLD. We constructed a steady‐state prevalence model to quantify this burden in the United States and Europe. Five models were constructed to estimate the burden of NAFLD in the United States and four European countries.

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