RIG‐I is a key antiviral interferon‐stimulated gene against hepatitis E virus regardless of interferon production
Lei Xu, Wenshi Wang, Yunlong Li, Xinying Zhou, Yuebang Yin, Yijin Wang, Robert A. de Man, Luc J.W. van der Laan, Fen Huang, Nassim Kamar, Maikel P. Peppelenbosch, Qiuwei Pan – 13 February 2017 – Interferons (IFNs) are broad antiviral cytokines that exert their function by inducing the transcription of hundreds of IFN‐stimulated genes (ISGs). However, little is known about the antiviral potential of these cellular effectors on hepatitis E virus (HEV) infection, the leading cause of acute hepatitis globally.