MicroRNA‐17 regulates autophagy to promote hepatic ischemia/reperfusion injury via suppression of signal transductions and activation of transcription‐3 expression

Shipeng Li, Jianjun Zhang, Zhen Wang, Tengfei Wang, Yao Yu, Jindan He, Haiming Zhang, Tao Yang, Zhongyang Shen – 19 August 2016 – Hepatic ischemia/reperfusion injury (IRI) represents an important clinical problem as related to liver resection or transplantation. However, the potential mechanism underlying hepatic IRI remains obscure. Recent evidence has indicated that microRNAs (miRNAs) participate in various hepatic pathophysiological processes via regulating autophagy.

A 10‐Year united network for organ sharing review of mortality and risk factors in young children awaiting liver transplantation

Daniel H. Leung, Amrita Narang, Charles G. Minard, Girish Hiremath, John A. Goss, Ross Shepherd – 19 August 2016 – Young children < 2 years of age with chronic end‐stage liver disease (YC2) are a uniquely vulnerable group listed for liver transplantation, characterized by a predominance of biliary atresia (BA). To investigate wait‐list mortality, associated risk factors, and outcomes of YC2, we evaluated United Network for Organ Sharing registry data from April 2003 to March 2013 for YC2 listed for deceased donor transplant (BA = 994; other chronic liver disease [CLD] = 221).

The underreporting of hepatocellular carcinoma to the cancer register and a log‐linear model to estimate a more correct incidence

Anna Törner, Knut Stokkeland, Åke Svensson, Paul W. Dickman, Rolf Hultcrantz, Scott Montgomery, Ann‐Sofi Duberg – 17 August 2016 – The Cancer Register (CR) in Sweden has reported that the incidence of primary liver cancer (PLC) has slowly declined over the last decades. Even though all cancers, irrespective of diagnostic method, should be reported to the CR, the PLC incidence may not reflect the true rate.

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

Volker M. Lauschke, Sabine U. Vorrink, Sabrina M.L. Moro, Fatemah Rezayee, Åsa Nordling, Delilah F.G. Hendriks, Catherine C. Bell, Rowena Sison‐Young, B. Kevin Park, Christopher E. Goldring, Ewa Ellis, Inger Johansson, Souren Mkrtchian, Tommy B. Andersson, Magnus Ingelman‐Sundberg – 17 August 2016 – Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing differentiated and dedifferentiated proliferating states in vivo.

Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ

Jing Yi, Li Lu, Kilangsungla Yanger, Wenqi Wang, Bo Hwa Sohn, Ben Z. Stanger, Min Zhang, James F. Martin, Jaffer A. Ajani, Junjie Chen, Ju‐Seog Lee, Shumei Song, Randy L.

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