Macrovascular invasion is not an absolute contraindication for living donor liver transplantation

Kwang‐Woong Lee, Suk‐Won Suh, YoungRok Choi, Jaehong Jeong, Nam‐Joon Yi, Hyeyoung Kim, Kyung Chul Yoon, Suk Kyun Hong, Hyo‐Sin Kim, Kyung‐Bun Lee, Kyung‐Suk Suh – 19 August 2016 – The indication of liver transplantation (LT) for the treatment of advanced hepatocellular carcinoma (HCC) is expanding. However, portal vein tumor thrombus (PVTT) has been still accepted as an absolute contraindication. We experienced an unexpectedly good prognosis in selected patients. Therefore, we tried to identify the prognostic factors after LT for HCC with major PVTT.

Liver grafts procured from donors after circulatory death have no increased risk of microthrombi formation

Cornelia J. Verhoeven, Tiarah C. Simon, Jeroen Jonge, Michael Doukas, Katharina Biermann, Herold J. Metselaar, Jan N. M. Ijzermans, Wojciech G. Polak – 19 August 2016 – Microthrombi formation provoked by warm ischemia and vascular stasis is thought to increase the risk of nonanastomotic strictures (NAS) in liver grafts obtained by donation after circulatory death (DCD). Therefore, potentially harmful intraoperative thrombolytic therapy has been suggested as a preventive strategy against NAS.

Sirtuin 2 aggravates postischemic liver injury by deacetylating mitogen‐activated protein kinase phosphatase‐1

Jie Wang, Hyoung‐Won Koh, Lu Zhou, Ui‐Jin Bae, Hwa‐Suk Lee, In Hyuk Bang, Sun‐O Ka, Seon‐Hee Oh, Eun Ju Bae, Byung‐Hyun Park – 17 August 2016 – Sirtuin 2 (Sirt2) is known to negatively regulate anoxia‐reoxygenation injury in myoblasts. Because protein levels of Sirt2 are increased in ischemia‐reperfusion (I/R)‐injured liver tissues, we examined whether Sirt2 is protective or detrimental against hepatic I/R injury. We overexpressed Sirt2 in the liver of C57BL/6 mice using a Sirt2 adenovirus.

Wnt signaling regulates hepatobiliary repair following cholestatic liver injury in mice

Hirohisa Okabe, Jing Yang, Kyle Sylakowski, Mladen Yovchev, Yoshitaka Miyagawa, Shanmugam Nagarajan, Maria Chikina, Michael Thompson, Michael Oertel, Hideo Baba, Satdarshan P Monga, Kari Nichole Nejak‐Bowen – 17 August 2016 – Hepatic repair is directed chiefly by the proliferation of resident mature epithelial cells. Furthermore, if predominant injury is to cholangiocytes, the hepatocytes can transdifferentiate to cholangiocytes to assist in the repair and vice versa, as shown by various fate‐tracing studies. However, the molecular bases of reprogramming remain elusive.

Hepatitis C virus transmission among human immunodeficiency virus‐infected men who have sex with men: Modeling the effect of behavioral and treatment interventions

Luisa Salazar‐Vizcaya, Roger D. Kouyos, Cindy Zahnd, Gilles Wandeler, Manuel Battegay, Katharine Elizabeth Anna Darling, Enos Bernasconi, Alexandra Calmy, Pietro Vernazza, Hansjakob Furrer, Matthias Egger, Olivia Keiser, Andri Rauch, the Swiss HIV Cohort Study – 17 August 2016 – The incidence of hepatitis C virus (HCV) infections among human immunodeficiency virus (HIV)‐infected men who have sex with men has increased in recent years and is associated with high‐risk sexual behavior.

Evaluation of proton pump inhibitor use on treatment outcomes with ledipasvir and sofosbuvir in a real‐world cohort study

Elliot B. Tapper, Bruce R. Bacon, Michael P. Curry, Douglas T. Dieterich, Steven L. Flamm, Lauren E. Guest, Kris V. Kowdley, Yoori Lee, Naoky C. Tsai, Zobair M. Younossi, Nezam H. Afdhal – 17 August 2016 – Many patients with chronic hepatitis C virus (HCV) are on prolonged proton‐pump inhibitor (PPI) therapy and wish to remain on PPI therapy once treatment for HCV starts. A preliminary report recently suggested decrease rates of sustained virological response (SVR) for patients taking concomitant PPI and ledipasvir/sofosbuvir (LDV/SOF).

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