Anti‐inflammatory signaling during ex vivo liver perfusion improves the preservation of pig liver grafts before transplantation

Nicolas Goldaracena, Juan Echeverri, Vinzent N. Spetzler, Johan M. Kaths, Andrew S. Barbas, Kristine S. Louis, Oyedele A. Adeyi, David R. Grant, Nazia Selzner, Markus Selzner – 24 August 2016 – Normothermic ex vivo liver perfusion (NEVLP) improves graft preservation by avoiding cold ischemia injury. We investigated whether the protective effects of NEVLP can be further improved by applying strategies targeted on reducing the activation of proinflammatory cytokines during perfusion. Livers retrieved under heart‐beating conditions were perfused for 4 hours.

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