Correlation of tumor response on computed tomography with pathological necrosis in hepatocellular carcinoma treated by chemoembolization before liver transplantation

Marco Dioguardi Burgio, Maxime Ronot, Onorina Bruno, Claire Francoz, Valérie Paradis, Laurent Castera, François Durand, Olivier Soubrane, Valérie Vilgrain – 20 August 2016 – The purpose of this article was to compare the results of Response Evaluation Criteria in Solid Tumors (RECIST), modified Response Evaluation Criteria in Solid Tumors (mRECIST), and European Association for the Study of the Liver (EASL) criteria for the evaluation of tumor necrosis in patients treated with transarterial chemoembolization before liver transplantation (LT) for hepatocellular carcinoma.

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

Zobair M. Younossi, Deirdre Blissett, Robert Blissett, Linda Henry, Maria Stepanova, Youssef Younossi, Andrei Racila, Sharon Hunt, Rachel Beckerman – 20 August 2016 – Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease. There is uncertainty around the economic burden of NAFLD. We constructed a steady‐state prevalence model to quantify this burden in the United States and Europe. Five models were constructed to estimate the burden of NAFLD in the United States and four European countries.

A 10‐Year united network for organ sharing review of mortality and risk factors in young children awaiting liver transplantation

Daniel H. Leung, Amrita Narang, Charles G. Minard, Girish Hiremath, John A. Goss, Ross Shepherd – 19 August 2016 – Young children < 2 years of age with chronic end‐stage liver disease (YC2) are a uniquely vulnerable group listed for liver transplantation, characterized by a predominance of biliary atresia (BA). To investigate wait‐list mortality, associated risk factors, and outcomes of YC2, we evaluated United Network for Organ Sharing registry data from April 2003 to March 2013 for YC2 listed for deceased donor transplant (BA = 994; other chronic liver disease [CLD] = 221).

MicroRNA‐17 regulates autophagy to promote hepatic ischemia/reperfusion injury via suppression of signal transductions and activation of transcription‐3 expression

Shipeng Li, Jianjun Zhang, Zhen Wang, Tengfei Wang, Yao Yu, Jindan He, Haiming Zhang, Tao Yang, Zhongyang Shen – 19 August 2016 – Hepatic ischemia/reperfusion injury (IRI) represents an important clinical problem as related to liver resection or transplantation. However, the potential mechanism underlying hepatic IRI remains obscure. Recent evidence has indicated that microRNAs (miRNAs) participate in various hepatic pathophysiological processes via regulating autophagy.

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