Plasma membrane‐bound G protein–coupled bile acid receptor attenuates liver ischemia/reperfusion injury via the inhibition of toll‐like receptor 4 signaling in mice

Haojun Yang, Haoming Zhou, Lin Zhuang, Johan Auwerx, Kristina Schoonjans, Xuehao Wang, Cheng Feng, Ling Lu – 6 September 2016 – The plasma membrane‐bound G protein–coupled bile acid receptor (TGR5) displays varied levels of expression in different tissues. TGR5‐induced liver protection has been demonstrated during several liver diseases, except during ischemia/reperfusion injury (IRI). Male adult wild‐type and TGR5 knockout (KO) mice were subjected to liver partial warm ischemia/reperfusion.

Role of donor hemodynamic trajectory in determining graft survival in liver transplantation from donation after circulatory death donors

Daniel J. Firl, Koji Hashimoto, Colin O'Rourke, Teresa Diago‐Uso, Masato Fujiki, Federico N. Aucejo, Cristiano Quintini, Dympna M. Kelly, Charles M. Miller, John J. Fung, Bijan Eghtesad – 6 September 2016 – Donation after circulatory death (DCD) donors show heterogeneous hemodynamic trajectories following withdrawal of life support. Impact of hemodynamics in DCD liver transplant is unclear, and objective measures of graft viability would ease transplant surgeon decision making and inform safe expansion of the donor organ pool.

Portopulmonary hypertension: Still an appropriate consideration for liver transplantation?

Suman Verma, Fiona Hand, Matthew J. Armstrong, Marie Vos, Douglas Thorburn, Terry Pan, John Klinck, Rachel H. Westbrook, Georg Auzinger, Andrew Bathgate, Steven Masson, Andrew Holt, Diarmaid D. Houlihan, James W. Ferguson – 4 September 2016 – Liver transplantation (LT) in patients with portopulmonary hypertension (PoPH) has historically resulted in unpredictable and often poor outcomes. The United Kingdom experience for the period 1992‐2012 is reported in this article.

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