Hypoxia‐driven Hif2a coordinates mouse liver regeneration by coupling parenchymal growth to vascular expansion

Philipp Kron, Michael Linecker, Perparim Limani, Andrea Schlegel, Patryk Kambakamba, Jean‐Marie Lehn, Claude Nicolau, Rolf Graf, Bostjan Humar, Pierre‐Alain Clavien – 15 September 2016 – Interaction between sinusoidal endothelial cells and hepatocytes is a prerequisite for liver function. Upon tissue loss, both liver cell populations need to be regenerated. Repopulation occurs in a coordinated pattern, first through the regeneration of parenchyme (hepatocytes), which then produces vascular endothelial growth factor (VEGF) to enable the subsequent angiogenic phase.

Workforce in hepatology: Update and a critical need for more information

Mark W. Russo, Ayman A. Koteish, Michael Fuchs, K. Gautham Reddy, Oren K. Fix – 15 September 2016 – The field of hepatology has experienced dramatic changes since the last workforce study in hepatology over 15 years ago. Hepatology practice has been dominated by hepatitis C but is now being overtaken by patients with nonalcoholic fatty liver disease. Expertise once attainable only through informal training, hepatology now has an accredited fellowship pathway and is recognized as a distinct discipline from gastroenterology with its own board certification.

Efficient nonarterialized mouse liver transplantation using 3‐dimensional–printed instruments

Graziano Oldani, Stéphanie Lacotte, Lorenzo A. Orci, Vaihere Delaune, Florence Slits, Quentin Gex, Philippe Morel, Laura Rubbia‐Brandt, Christian Toso – 12 September 2016 – Because of the wide availability of genetically modified animals, mouse orthotopic liver transplantation is often preferred over rat liver transplantation. We present a simplified mouse liver transplantation technique and compare transplantation outcomes with versus without hepatic artery anastomosis. Instruments for liver implantation were designed and printed with a 3‐dimensional (3D) printer.

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