Stella Chai, Kai‐Yu Ng, Man Tong, Eunice Y. Lau, Terence K. Lee, Kwok Wah Chan, Yun‐Fei Yuan, Tan‐To Cheung, Siu‐Tim Cheung, Xiao‐Qi Wang, Nathalie Wong, Chung‐Mau Lo, Kwan Man, Xin‐Yuan Guan, Stephanie Ma – 17 September 2016 – Wnt/β‐catenin signaling is activated in CD133 liver cancer stem cells (CSCs), a subset of cells known to be a root of tumor recurrence and therapy resistance in hepatocellular carcinoma (HCC). However, the regulatory mechanism of this pathway in CSCs remains unclear.

Akiko Eguchi, Raul G. Lazaro, Jiaohong Wang, Jihoon Kim, Davide Povero, Brandon Willliams, Samuel B. Ho, Peter Stärkel, Bernd Schnabl, Lucila Ohno‐Machado, Hidekazu Tsukamoto, Ariel E. Feldstein – 17 September 2016 – Extracellular vesicles (EVs) released during cell stress, or demise, can contain a barcode of the cell origin, including specific microRNAs (miRNAs). Here, we tested the hypothesis that during early alcoholic steatohepatitis (ASH) development, hepatocytes (HCs) release EVs with an miRNA signature that can be measured in circulation.

Amalia Gastaldelli, Melania Gaggini, Giuseppe Daniele, Demetrio Ciociaro, Eugenio Cersosimo, Devjit Tripathy, Curtis Triplitt, Peter Fox, Nicolas Musi, Ralph DeFronzo, Patricia Iozzo – 17 September 2016 – Glucagon‐like peptide 1 (GLP‐1) receptor agonists (GLP‐1‐RAs) act on multiple tissues, in addition to the pancreas. Recent studies suggest that GLP‐1‐RAs act on liver and adipose tissue to reduce insulin resistance (IR). Thus, we evaluated the acute effects of exenatide (EX) on hepatic (Hep‐IR) and adipose (Adipo‐IR) insulin resistance and glucose uptake.

Claudia D. Fuchs, Peter Schwabl, Thomas Reiberger, Michael Trauner – 16 September 2016

Lucas A. Hill, David L. Wyles – 16 September 2016

Lucas A. Hill, David L. Wyles – 16 September 2016

Satoshi Tanaka, Hayato Hikita, Tomohide Tatsumi, Ryotaro Sakamori, Yasutoshi Nozaki, Sadatsugu Sakane, Yuto Shiode, Tasuku Nakabori, Yoshinobu Saito, Naoki Hiramatsu, Keisuke Tabata, Tsuyoshi Kawabata, Maho Hamasaki, Hidetoshi Eguchi, Hiroaki Nagano, Tamotsu Yoshimori, Tetsuo Takehara – 16 September 2016 – Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. It encompasses a spectrum ranging from simple steatosis to fatty liver with hepatocellular injury, termed nonalcoholic steatohepatitis.

Claudia D. Fuchs, Peter Schwabl, Thomas Reiberger, Michael Trauner – 16 September 2016

Muhammad Asif Qureshi, Yong Ook Kim, Detlef Schuppan – 15 September 2016

Mark W. Russo, Ayman A. Koteish, Michael Fuchs, K. Gautham Reddy, Oren K. Fix – 15 September 2016 – The field of hepatology has experienced dramatic changes since the last workforce study in hepatology over 15 years ago. Hepatology practice has been dominated by hepatitis C but is now being overtaken by patients with nonalcoholic fatty liver disease. Expertise once attainable only through informal training, hepatology now has an accredited fellowship pathway and is recognized as a distinct discipline from gastroenterology with its own board certification.