Encapsulated platelets modulate kupffer cell activation and reduce oxidative stress in a model of acute liver failure
Mónica Luján López, Carolina Uribe‐Cruz, Alessandro Osvaldt, Carlos Oscar Kieling, Laura Simon, Santiago Tobar, Michael Andrades, Ursula Matte – 10 August 2016 – Acute liver failure (ALF) is characterized by massive hepatocyte cell death. Kupffer cells (KC) are the first cells to be activated after liver injury. They secrete cytokines and produce reactive oxygen species, leading to apoptosis of hepatocytes. In a previous study, we showed that encapsulated platelets (PLTs) increase survival in a model of ALF. Here, we investigate how PLTs exert their beneficial effect.