The dark side of the moon: AKT as a tumor suppressor in the liver?
Xin Chen, Diego F. Calvisi – 12 August 2016
Focusing on beta‐catenin activating mutations to refine liver tumor profiling
Sabine Colnot – 12 August 2016
Impact of donor‐recipient genetic relationship on outcome of living donor liver transplantation
Mahmoud Abdelwahab Ali, Mohamed Morsi Elshobari, Tarek Salah, Al‐Refaey Kandeel, Ahmad Mohammad Sultan, Ahmad Nabieh Elghawalby, Ahmed Shehta, Usama Elsayed, Omar Fathy, Amr Yassen, Mohamed Abdel Wahab – 12 August 2016 – Living donor liver transplantation (LDLT) is a valuable option for expanding the donor pool, especially in localities where deceased organ harvesting is not allowed. In addition, rejection rates were found to be lower in LDLT, which is attributed to the fact that LDLT is usually performed between relatives.
Development of a normothermic extracorporeal liver perfusion system toward improving viability and function of human extended criteria donor livers
Maria Franzini, Davide Ghinolfi, Daniele Pezzati, Franco Filipponi, Vanna Fierabracci, Aldo Paolicchi, Laura Caponi – 12 August 2016
Longterm outcomes of stent placement for hepatic venous outflow obstruction in adult liver transplantation recipients
Hee Ho Chu, Nam‐Joon Yi, Hyo‐Cheol Kim, Kwang‐Woong Lee, Kyung‐Suk Suh, Hwan Jun Jae, Jin Wook Chung – 12 August 2016 – The purpose of this study was to evaluate the longterm outcomes of stent placement for a hepatic venous outflow obstruction in adult liver transplantation recipients. From June 2002 to March 2014, 23 patients were confirmed to have a hepatic venous outflow obstruction after liver transplantation (18 of 789 living donors [2.3%] and 5 of 449 deceased donors [1.1%]) at our institute.
Upstream regulators of hepatic Wnt/β‐catenin activity control liver metabolic zonation, development, and regeneration
Laure‐Alix Clerbaux, Rita Manco, Isabelle Leclercq – 12 August 2016
Encapsulated platelets modulate kupffer cell activation and reduce oxidative stress in a model of acute liver failure
Mónica Luján López, Carolina Uribe‐Cruz, Alessandro Osvaldt, Carlos Oscar Kieling, Laura Simon, Santiago Tobar, Michael Andrades, Ursula Matte – 10 August 2016 – Acute liver failure (ALF) is characterized by massive hepatocyte cell death. Kupffer cells (KC) are the first cells to be activated after liver injury. They secrete cytokines and produce reactive oxygen species, leading to apoptosis of hepatocytes. In a previous study, we showed that encapsulated platelets (PLTs) increase survival in a model of ALF. Here, we investigate how PLTs exert their beneficial effect.
Graft‐to‐recipient weight ratio threshold adjusted to the model for end‐stage liver disease score for living donor liver transplantation
Altan Alim, Yalcin Erdogan, Yildiray Yuzer, Yaman Tokat, Arzu Oezcelik – 10 August 2016 – The graft‐to‐recipient weight ratio (GRWR) is an important selection criterion for living donor liver transplantation (LDLT). The generally accepted threshold is known to be 0.8%. We believe that this threshold can be reduced under certain conditions. The aim of this study was to evaluate the results of these patients with GRWR < 0.8%. Between 2004 and 2015, 649 patients underwent right lobe LDLT for end‐stage liver disease in adult patients. All recipients who had GRWR < 0.8% were identified.
The brain gets its say: Hepatic encephalopathy and its evolving role in transplant priority
Jasmohan S. Bajaj, Patrick S. Kamath – 10 August 2016
Robotic liver donor right hepatectomy: A pure, minimally invasive approach
Po‐Da Chen, Chao‐Ying Wu, Rey‐Heng Hu, Cheng‐Maw Ho, Po‐Huang Lee, Hong‐Shiee Lai, Ming‐Tsan Lin, Yao‐Ming Wu – 10 August 2016 – Right hepatectomy for a living liver donor via a pure minimally invasive approach is a challenging procedure and only a few cases have been reported. Between May 2013 and August 2015, 13 patients underwent robotic living donor right hepatectomy in our institute, and 54 patients received open surgery. In this series, no conversion was conducted for robotic donor right hepatectomy.