Angiopoietin‐like protein 1 antagonizes MET receptor activity to repress sorafenib resistance and cancer stemness in hepatocellular carcinoma

Hsin‐An Chen, Tsang‐Chih Kuo, Chi‐Feng Tseng, Jui‐Ti Ma, Shu‐Ting Yang, Chia‐Jui Yen, Ching‐Yao Yang, Shian‐Ying Sung, Jen‐Liang Su – 17 August 2016 – Angiopoietin‐like protein 1 (ANGPTL1) has been shown to act as a tumor suppressor by inhibiting angiogenesis, cancer invasion, and metastasis. However, little is known about the effects of ANGPTL1 on sorafenib resistance and cancer stem cell properties in hepatocellular carcinoma (HCC) and the mechanism underlying these effects.

Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ

Jing Yi, Li Lu, Kilangsungla Yanger, Wenqi Wang, Bo Hwa Sohn, Ben Z. Stanger, Min Zhang, James F. Martin, Jaffer A. Ajani, Junjie Chen, Ju‐Seog Lee, Shumei Song, Randy L.

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

Volker M. Lauschke, Sabine U. Vorrink, Sabrina M.L. Moro, Fatemah Rezayee, Åsa Nordling, Delilah F.G. Hendriks, Catherine C. Bell, Rowena Sison‐Young, B. Kevin Park, Christopher E. Goldring, Ewa Ellis, Inger Johansson, Souren Mkrtchian, Tommy B. Andersson, Magnus Ingelman‐Sundberg – 17 August 2016 – Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing differentiated and dedifferentiated proliferating states in vivo.

The underreporting of hepatocellular carcinoma to the cancer register and a log‐linear model to estimate a more correct incidence

Anna Törner, Knut Stokkeland, Åke Svensson, Paul W. Dickman, Rolf Hultcrantz, Scott Montgomery, Ann‐Sofi Duberg – 17 August 2016 – The Cancer Register (CR) in Sweden has reported that the incidence of primary liver cancer (PLC) has slowly declined over the last decades. Even though all cancers, irrespective of diagnostic method, should be reported to the CR, the PLC incidence may not reflect the true rate.

Outcome of living donor liver transplantation using right liver allografts with multiple arterial supply

Kyo Won Lee, Sanghoon Lee, Jeungmin Huh, Chan Woo Cho, Nuri Lee, Hye Seung Kim, Kyunga Kim, Jong Man Kim, Gyu Seong Choi, Choon Hyuck David Kwon, Jae‐Won Joh, Suk‐Koo Lee – 12 August 2016 – A right liver graft with multiple hepatic artery (HA) stumps can be found in approximately 5% of living donor liver transplantation (LDLT) using a right lobe graft. From January 2000 to June 2014, 1149 patients underwent LDLT procedures. Thirty patients with LDLT using a right lobe graft with multiple HA stumps and 149 patients with LDLT using a right lobe graft with a single HA stump were enrolled.

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