Encapsulated platelets modulate kupffer cell activation and reduce oxidative stress in a model of acute liver failure

Mónica Luján López, Carolina Uribe‐Cruz, Alessandro Osvaldt, Carlos Oscar Kieling, Laura Simon, Santiago Tobar, Michael Andrades, Ursula Matte – 10 August 2016 – Acute liver failure (ALF) is characterized by massive hepatocyte cell death. Kupffer cells (KC) are the first cells to be activated after liver injury. They secrete cytokines and produce reactive oxygen species, leading to apoptosis of hepatocytes. In a previous study, we showed that encapsulated platelets (PLTs) increase survival in a model of ALF. Here, we investigate how PLTs exert their beneficial effect.

Graft‐to‐recipient weight ratio threshold adjusted to the model for end‐stage liver disease score for living donor liver transplantation

Altan Alim, Yalcin Erdogan, Yildiray Yuzer, Yaman Tokat, Arzu Oezcelik – 10 August 2016 – The graft‐to‐recipient weight ratio (GRWR) is an important selection criterion for living donor liver transplantation (LDLT). The generally accepted threshold is known to be 0.8%. We believe that this threshold can be reduced under certain conditions. The aim of this study was to evaluate the results of these patients with GRWR < 0.8%. Between 2004 and 2015, 649 patients underwent right lobe LDLT for end‐stage liver disease in adult patients. All recipients who had GRWR < 0.8% were identified.

Robotic liver donor right hepatectomy: A pure, minimally invasive approach

Po‐Da Chen, Chao‐Ying Wu, Rey‐Heng Hu, Cheng‐Maw Ho, Po‐Huang Lee, Hong‐Shiee Lai, Ming‐Tsan Lin, Yao‐Ming Wu – 10 August 2016 – Right hepatectomy for a living liver donor via a pure minimally invasive approach is a challenging procedure and only a few cases have been reported. Between May 2013 and August 2015, 13 patients underwent robotic living donor right hepatectomy in our institute, and 54 patients received open surgery. In this series, no conversion was conducted for robotic donor right hepatectomy.

Novel educational interventions in residency increase knowledge of chronic liver disease and career interest in hepatology

Adam E. Mikolajczyk, Jeanne M. Farnan, John F. McConville, Donald M. Jensen, K. Gautham Reddy, Helen S. Te, Nancy Reau, Andrew I. Aronsohn – 10 August 2016 – There is an increasing burden of chronic liver disease (CLD) in the United States but a significant shortage of hepatologists. Thus, it is necessary to develop new recruitment strategies to the field of hepatology as well as ensure that non‐gastroenterology‐trained physicians are able to capably assist in the care of CLD.

Bone marrow stem cells and their niche components are adversely affected in advanced cirrhosis of the liver

Chhagan Bihari, Lovkesh Anand, Sheetalnath Rooge, Dhananjay Kumar, Priyanka Saxena, Smriti Shubham, Sukriti, Nirupma Trehanpati, Guresh Kumar, Viniyendra Pamecha, Shvetank Sharma, Archana Rastogi, Anupam Kumar, Shiv K. Sarin – 3 August 2016 – Bone marrow (BM) is a reservoir for immune and hematopoietic cells and critical for tissue repair and regeneration. All of these functions are severely altered in cirrhosis. We investigated the cellular and functional state of BM in cirrhosis patients.

Bone marrow stem cells and their niche components are adversely affected in advanced cirrhosis of the liver

Chhagan Bihari, Lovkesh Anand, Sheetalnath Rooge, Dhananjay Kumar, Priyanka Saxena, Smriti Shubham, Sukriti, Nirupma Trehanpati, Guresh Kumar, Viniyendra Pamecha, Shvetank Sharma, Archana Rastogi, Anupam Kumar, Shiv K. Sarin – 3 August 2016 – Bone marrow (BM) is a reservoir for immune and hematopoietic cells and critical for tissue repair and regeneration. All of these functions are severely altered in cirrhosis. We investigated the cellular and functional state of BM in cirrhosis patients.

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