Graft‐to‐recipient weight ratio threshold adjusted to the model for end‐stage liver disease score for living donor liver transplantation

Altan Alim, Yalcin Erdogan, Yildiray Yuzer, Yaman Tokat, Arzu Oezcelik – 10 August 2016 – The graft‐to‐recipient weight ratio (GRWR) is an important selection criterion for living donor liver transplantation (LDLT). The generally accepted threshold is known to be 0.8%. We believe that this threshold can be reduced under certain conditions. The aim of this study was to evaluate the results of these patients with GRWR < 0.8%. Between 2004 and 2015, 649 patients underwent right lobe LDLT for end‐stage liver disease in adult patients. All recipients who had GRWR < 0.8% were identified.

Encapsulated platelets modulate kupffer cell activation and reduce oxidative stress in a model of acute liver failure

Mónica Luján López, Carolina Uribe‐Cruz, Alessandro Osvaldt, Carlos Oscar Kieling, Laura Simon, Santiago Tobar, Michael Andrades, Ursula Matte – 10 August 2016 – Acute liver failure (ALF) is characterized by massive hepatocyte cell death. Kupffer cells (KC) are the first cells to be activated after liver injury. They secrete cytokines and produce reactive oxygen species, leading to apoptosis of hepatocytes. In a previous study, we showed that encapsulated platelets (PLTs) increase survival in a model of ALF. Here, we investigate how PLTs exert their beneficial effect.

Bone marrow stem cells and their niche components are adversely affected in advanced cirrhosis of the liver

Chhagan Bihari, Lovkesh Anand, Sheetalnath Rooge, Dhananjay Kumar, Priyanka Saxena, Smriti Shubham, Sukriti, Nirupma Trehanpati, Guresh Kumar, Viniyendra Pamecha, Shvetank Sharma, Archana Rastogi, Anupam Kumar, Shiv K. Sarin – 3 August 2016 – Bone marrow (BM) is a reservoir for immune and hematopoietic cells and critical for tissue repair and regeneration. All of these functions are severely altered in cirrhosis. We investigated the cellular and functional state of BM in cirrhosis patients.

Bone marrow stem cells and their niche components are adversely affected in advanced cirrhosis of the liver

Chhagan Bihari, Lovkesh Anand, Sheetalnath Rooge, Dhananjay Kumar, Priyanka Saxena, Smriti Shubham, Sukriti, Nirupma Trehanpati, Guresh Kumar, Viniyendra Pamecha, Shvetank Sharma, Archana Rastogi, Anupam Kumar, Shiv K. Sarin – 3 August 2016 – Bone marrow (BM) is a reservoir for immune and hematopoietic cells and critical for tissue repair and regeneration. All of these functions are severely altered in cirrhosis. We investigated the cellular and functional state of BM in cirrhosis patients.

Liver protects metastatic prostate cancer from induced death by activating E‐cadherin signaling

Bo Ma, Sarah E. Wheeler, Amanda M. Clark, Diana L. Whaley, Min Yang, Alan Wells – 2 August 2016 – Liver is one of the most common sites of cancer metastasis. Once disseminated, the prognosis is poor as these tumors often display generalized chemoresistance, particularly for carcinomas that derive not from the aerodigestive tract. When these cancers seed the liver, the aggressive cells usually undergo a mesenchymal to epithelial reverting transition that both aids colonization and renders the tumor cells chemoresistant.

Subscribe to