Hepatic encephalopathy expands the predictivity of model for end‐stage liver disease in liver transplant setting: Evidence by means of 2 independent cohorts

Cristina Lucidi, Stefano Ginanni Corradini, Juan G. Abraldes, Manuela Merli, Puneeta Tandon, Flaminia Ferri, Lucia Parlati, Barbara Lattanzi, Edoardo Poli, Vincenza Di Gregorio, Alessio Farcomeni, Oliviero Riggio – 19 July 2016 – Despite its documented prognostic relevance, hepatic encephalopathy (HE) is not considered in liver transplantation (LT) due to its possible poor objectivity. To override this problem, we aimed to analyze if an objective diagnosis of HE may confer additional mortality risk beyond MELD.

Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo

Natalie Porat‐Shliom, Amber J. Tietgens, Christina M. Itallie, Lynn Vitale‐Cross, Michal Jarnik, Olivia J. Harding, James M. Anderson, J. Silvio Gutkind, Roberto Weigert, Irwin M. Arias – 11 July 2016 – Liver kinase B1 (LKB1) and its downstream effector AMP‐activated protein kinase (AMPK) play critical roles in polarity establishment by regulating membrane trafficking and energy metabolism. In collagen sandwich‐cultured hepatocytes, loss of LKB1 or AMPK impaired apical ABCB11 (Bsep) trafficking and bile canalicular formation.

IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell‐death mediator receptor‐interacting protein kinase 1

Christiane Koppe, Patricia Verheugd, Jérémie Gautheron, Florian Reisinger, Karina Kreggenwinkel, Christoph Roderburg, Luca Quagliata, Luigi Terracciano, Nikolaus Gassler, René H. Tolba, Yannick Boege, Achim Weber, Michael Karin, Mark Luedde, Ulf P.

Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation

Shirish Paranjpe, William C. Bowen, Wendy M. Mars, Anne Orr, Meagan M. Haynes, Marie C. DeFrances, Silvia Liu, George C. Tseng, Anastasia Tsagianni, George K. Michalopoulos – 11 July 2016 – Receptor tyrosine kinases MET and epidermal growth factor receptor (EGFR) are critically involved in initiation of liver regeneration. Other cytokines and signaling molecules also participate in the early part of the process. Regeneration employs effective redundancy schemes to compensate for the missing signals.

Subscribe to