Mouse model of primary biliary cholangitis with a striking female predominance: A new powerful research tool
Diego Vergani, Giorgina Mieli‐Vergani – 7 July 2016
Nonalcoholic Fatty Liver Disease: Epidemiology, Natural History, and Diagnostic Challenges
George Cholankeril, Ryan B. Perumpail, Edward A. Pham, Aijaz Ahmed, Stephen A. Harrison – 7 July 2016
Hypothalamic kappa opioid receptor mediates both diet‐induced and melanin concentrating hormone–induced liver damage through inflammation and endoplasmic reticulum stress
Monica Imbernon, Estrella Sanchez‐Rebordelo, Amparo Romero‐Picó, Imre Kalló, Melissa J. Chee, Begoña Porteiro, Omar Al‐Massadi, Cristina Contreras, Johan Fernø, Ana Senra, Rosalia Gallego, Cintia Folgueira, Luisa M. Seoane, Margriet van Gestel, Roger A. Adan, Zsolt Liposits, Carlos Dieguez, Miguel López, Ruben Nogueiras – 7 July 2016 – The opioid system is widely known to modulate the brain reward system and thus affect the behavior of humans and other animals, including feeding. We hypothesized that the hypothalamic opioid system might also control energy metabolism in peripheral tissues.
Withdrawal of posttransplant hepatitis B virus prophylaxis: A blind test
Bruno Roche, Didier Samuel – 7 July 2016
Nonalcoholic Fatty Liver Disease: Epidemiology, Natural History, and Diagnostic Challenges
George Cholankeril, Ryan B. Perumpail, Edward A. Pham, Aijaz Ahmed, Stephen A. Harrison – 7 July 2016
Balancing quality with quantity: The role of palliative care in managing decompensated cirrhosis
Karl M. Langberg, Tamar H. Taddei – 7 July 2016
Generation of pediatric liver cancer patient–derived xenograft platforms for pediatric liver cancer: A critical stage in the development of anticancer treatments
Gregory Tiao, James Geller, Nikolai A. Timchenko – 30 June 2016
Endothelial notch signaling is essential to prevent hepatic vascular malformations in mice
Henar Cuervo, Corinne M. Nielsen, Douglas A. Simonetto, Linda Ferrell, Vijay H. Shah, Rong A. Wang – 30 June 2016 – Liver vasculature is crucial for adequate hepatic functions. Global deletion of Notch signaling in mice results in liver vascular pathologies. However, whether Notch in endothelium is essential for hepatic vascular structure and function remains unknown. To uncover the function of endothelial Notch in the liver, we deleted Rbpj, a transcription factor mediating all canonical Notch signaling, or Notch1 from the endothelium of postnatal mice.
Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives
Juan P. Arab, Saul J. Karpen, Paul A. Dawson, Marco Arrese, Michael Trauner – 30 June 2016 – Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide and an important risk factor for both hepatic and cardiometabolic mortality. The rapidly increasing prevalence of this disease and of its aggressive form nonalcoholic steatohepatitis (NASH) will require novel therapeutic approaches to prevent disease progression to advanced fibrosis or cirrhosis and cancer.
Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice
Yang Xu, Fei Li, Munaf Zalzala, Jiesi Xu, Frank J. Gonzalez, Luciano Adorini, Yoon‐Kwang Lee, Liya Yin, Yanqiao Zhang – 30 June 2016 – Activation of farnesoid X receptor (FXR) markedly attenuates development of atherosclerosis in animal models. However, the underlying mechanism is not well elucidated. Here, we show that the FXR agonist, obeticholic acid (OCA), increases fecal cholesterol excretion and macrophage reverse cholesterol transport (RCT) dependent on activation of hepatic FXR. OCA does not increase biliary cholesterol secretion, but inhibits intestinal cholesterol absorption.