End‐ischemic reconditioning of liver allografts: Controlling the rewarming

Dieter Paul Hoyer, Andreas Paul, Sebastian Luer, Henning Reis, Patrik Efferz, Thomas Minor – 11 July 2016 – Different nonhypothermic preservation modalities have shown beneficial effects in liver transplantation models. This study compares controlled oxygenated rewarming (COR) to normothermic machine perfusion (NMP) to resuscitate liver grafts following cold storage (CS). Porcine livers were preserved for 18 hours by CS.

Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation

Shirish Paranjpe, William C. Bowen, Wendy M. Mars, Anne Orr, Meagan M. Haynes, Marie C. DeFrances, Silvia Liu, George C. Tseng, Anastasia Tsagianni, George K. Michalopoulos – 11 July 2016 – Receptor tyrosine kinases MET and epidermal growth factor receptor (EGFR) are critically involved in initiation of liver regeneration. Other cytokines and signaling molecules also participate in the early part of the process. Regeneration employs effective redundancy schemes to compensate for the missing signals.

IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell‐death mediator receptor‐interacting protein kinase 1

Christiane Koppe, Patricia Verheugd, Jérémie Gautheron, Florian Reisinger, Karina Kreggenwinkel, Christoph Roderburg, Luca Quagliata, Luigi Terracciano, Nikolaus Gassler, René H. Tolba, Yannick Boege, Achim Weber, Michael Karin, Mark Luedde, Ulf P.

Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo

Natalie Porat‐Shliom, Amber J. Tietgens, Christina M. Itallie, Lynn Vitale‐Cross, Michal Jarnik, Olivia J. Harding, James M. Anderson, J. Silvio Gutkind, Roberto Weigert, Irwin M. Arias – 11 July 2016 – Liver kinase B1 (LKB1) and its downstream effector AMP‐activated protein kinase (AMPK) play critical roles in polarity establishment by regulating membrane trafficking and energy metabolism. In collagen sandwich‐cultured hepatocytes, loss of LKB1 or AMPK impaired apical ABCB11 (Bsep) trafficking and bile canalicular formation.

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