Bone marrow stem cells and their niche components are adversely affected in advanced cirrhosis of the liver

Chhagan Bihari, Lovkesh Anand, Sheetalnath Rooge, Dhananjay Kumar, Priyanka Saxena, Smriti Shubham, Sukriti, Nirupma Trehanpati, Guresh Kumar, Viniyendra Pamecha, Shvetank Sharma, Archana Rastogi, Anupam Kumar, Shiv K. Sarin – 3 August 2016 – Bone marrow (BM) is a reservoir for immune and hematopoietic cells and critical for tissue repair and regeneration. All of these functions are severely altered in cirrhosis. We investigated the cellular and functional state of BM in cirrhosis patients.

Liver protects metastatic prostate cancer from induced death by activating E‐cadherin signaling

Bo Ma, Sarah E. Wheeler, Amanda M. Clark, Diana L. Whaley, Min Yang, Alan Wells – 2 August 2016 – Liver is one of the most common sites of cancer metastasis. Once disseminated, the prognosis is poor as these tumors often display generalized chemoresistance, particularly for carcinomas that derive not from the aerodigestive tract. When these cancers seed the liver, the aggressive cells usually undergo a mesenchymal to epithelial reverting transition that both aids colonization and renders the tumor cells chemoresistant.

Prospective study of guideline‐tailored therapy with direct‐acting antivirals for hepatitis C virus‐associated mixed cryoglobulinemia

Laura Gragnani, Marcella Visentini, Elisa Fognani, Teresa Urraro, Adriano De Santis, Luisa Petraccia, Marie Perez, Giorgia Ceccotti, Stefania Colantuono, Milica Mitrevski, Cristina Stasi, Martina Del Padre, Monica Monti, Elena Gianni, Alessandro Pulsoni, Massimo Fiorilli, Milvia Casato, Anna Linda Zignego – 2 August 2016 – Hepatitis C virus (HCV)‐associated mixed cryoglobulinemia (MC) vasculitis commonly regresses upon virus eradication, but conventional therapy with pegylated interferon and ribavirin yields approximately 40% sustained virologic responses (SVR).

Nogo‐B receptor deficiency increases liver X receptor alpha nuclear translocation and hepatic lipogenesis through an adenosine monophosphate–activated protein kinase alpha–dependent pathway

Wenquan Hu, Wenwen Zhang, Yuanli Chen, Ujala Rana, Ru‐jeng Teng, Yajun Duan, Zhong Liu, Baofeng Zhao, Jamie Foeckler, Hartmut Weiler, Rachel E. Kallinger, Michael J. Thomas, Kezhong Zhang, Jihong Han, Qing Robert Miao – 2 August 2016 – Nogo‐B receptor (NgBR) was identified as a specific receptor for binding Nogo‐B and is essential for the stability of Niemann‐Pick type C2 protein (NPC2) and NPC2‐dependent cholesterol trafficking.

Systemic inflammation in decompensated cirrhosis: Characterization and role in acute‐on‐chronic liver failure

Joan Clària, Rudolf E. Stauber, Minneke J. Coenraad, Richard Moreau, Rajiv Jalan, Marco Pavesi, Àlex Amorós, Esther Titos, José Alcaraz‐Quiles, Karl Oettl, Manuel Morales‐Ruiz, Paolo Angeli, Marco Domenicali, Carlo Alessandria, Alexander Gerbes, Julia Wendon, Frederik Nevens, Jonel Trebicka, Wim Laleman, Faouzi Saliba, Tania M.

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