Giulio Marchesini, Salvatore Petta, Riccardo Dalle Grave – 11 December 2015 – Fatty liver accumulation results from an imbalance between lipid deposition and removal, driven by the hepatic synthesis of triglycerides and de novo lipogenesis. The habitual diet plays a relevant role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), and both risky (e.g., fructose) and protective foods (Mediterranean diet) have been described, but the contribution of excess calories remains pivotal. Accordingly, weight loss is the most effective way to promote liver fat removal.

Giulio Marchesini, Salvatore Petta, Riccardo Dalle Grave – 11 December 2015 – Fatty liver accumulation results from an imbalance between lipid deposition and removal, driven by the hepatic synthesis of triglycerides and de novo lipogenesis. The habitual diet plays a relevant role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), and both risky (e.g., fructose) and protective foods (Mediterranean diet) have been described, but the contribution of excess calories remains pivotal. Accordingly, weight loss is the most effective way to promote liver fat removal.

Xi Lan, Jidong Yan, Juan Ren, Bo Zhong, Jing Li, Yue Li, Li Liu, Jing Yi, Qingzhu Sun, Xudong Yang, Jian Sun, Liesu Meng, Wenhua Zhu, Rikard Holmdahl, Dongmin Li, Shemin Lu – 11 December 2015 – Cholesterol metabolism disorder in hepatocytes predicts a higher risk of metabolic syndrome (MetS). Long noncoding RNAs (lncRNAs) have emerged as critical players in cellular cholesterol metabolism, but their functions are not systematically clarified.

Aynur Unalp‐Arida, Constance E. Ruhl – 10 December 2015 – Nonalcoholic fatty liver disease (NAFLD) contributes to premature death along with obesity, diabetes, and cardiovascular disease (CVD). We examined whether hepatic steatosis (HS) on ultrasound and liver enzyme activities were associated with increased liver disease mortality in the U.S. National Health and Nutrition Examination Survey (NHANES), 1988‐1994, with up to 23 years of linked‐mortality data.

Annie‐Carole Tosello‐Trampont, Peter Krueger, Sowmya Narayanan, Susan G. Landes, Norbert Leitinger, Young S. Hahn – 10 December 2015 – Nonalcoholic steatohepatitis (NASH) affects 3%‐5% of the U.S. population, having severe clinical complications to the development of fibrosis and end‐stage liver diseases, such as cirrhosis and hepatocellular carcinoma. A critical cause of NASH is chronic systemic inflammation promoted by innate immune cells, such as liver macrophages (Mϕ) and natural killer (NK) cells.

Maura Dandri, Jan‐Hendrik Bockmann – 10 December 2015

Hyuk Soo Eun, Won‐Il Jeong – 10 December 2015

Richard Gilroy, John Bucuvalas – 10 December 2015

Tung‐Hung Su, Chun‐Jen Liu, Tai‐Chung Tseng, Shih‐Wan Chou, Chen‐Hua Liu, Hung‐Chih Yang, Shang‐Ju Wu, Pei‐Jer Chen, Ding‐Shinn Chen, Chi‐Ling Chen, Jia‐Horng Kao – 10 December 2015 – Chronic hepatitis C viral (HCV) infection has been associated with non‐Hodgkin's lymphoma (NHL); however, the results are inconsistent among regions with different HCV prevalence rates. The temporal relationship, risk estimates, and association between HCV and lymphoid‐neoplasms remain unclear.

Angelo Sangiovanni, Massimo Colombo – 10 December 2015