Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo

Natalie Porat‐Shliom, Amber J. Tietgens, Christina M. Itallie, Lynn Vitale‐Cross, Michal Jarnik, Olivia J. Harding, James M. Anderson, J. Silvio Gutkind, Roberto Weigert, Irwin M. Arias – 11 July 2016 – Liver kinase B1 (LKB1) and its downstream effector AMP‐activated protein kinase (AMPK) play critical roles in polarity establishment by regulating membrane trafficking and energy metabolism. In collagen sandwich‐cultured hepatocytes, loss of LKB1 or AMPK impaired apical ABCB11 (Bsep) trafficking and bile canalicular formation.

Hypothalamic kappa opioid receptor mediates both diet‐induced and melanin concentrating hormone–induced liver damage through inflammation and endoplasmic reticulum stress

Monica Imbernon, Estrella Sanchez‐Rebordelo, Amparo Romero‐Picó, Imre Kalló, Melissa J. Chee, Begoña Porteiro, Omar Al‐Massadi, Cristina Contreras, Johan Fernø, Ana Senra, Rosalia Gallego, Cintia Folgueira, Luisa M. Seoane, Margriet van Gestel, Roger A. Adan, Zsolt Liposits, Carlos Dieguez, Miguel López, Ruben Nogueiras – 7 July 2016 – The opioid system is widely known to modulate the brain reward system and thus affect the behavior of humans and other animals, including feeding. We hypothesized that the hypothalamic opioid system might also control energy metabolism in peripheral tissues.

Zinc finger protein 191 inhibits hepatocellular carcinoma metastasis through discs large 1‐mediated yes‐associated protein inactivation

Di Wu, Guoyuan Liu, Yufeng Liu, Hexige Saiyin, Chenji Wang, Zhen Wei, Wenjiao Zen, Danyang Liu, Qi Chen, Zhonghua Zhao, Liping Zou, Haojie Huang, Songmin Jiang, Long Yu – 30 June 2016 – Interplay between cell polarity module Scribble‐Lethal Giant Larvae‐Discs Large 1 (DLG1) and Yes‐associated protein (YAP) appears critical in tumor metastasis. We identified zinc finger protein 191 (ZNF191) as a metastasis suppressor acting through DLG‐YAP crosstalk in hepatocellular carcinoma (HCC).

Programmed death ligand 1 expression in hepatocellular carcinoma: Relationship With clinical and pathological features

Julien Calderaro, Benoît Rousseau, Giuliana Amaddeo, Marion Mercey, Cécile Charpy, Charlotte Costentin, Alain Luciani, Elie‐Serge Zafrani, Alexis Laurent, Daniel Azoulay, Fouad Lafdil, Jean‐Michel Pawlotsky – 30 June 2016 – The prognosis of hepatocellular carcinoma (HCC) remains poor, with only one third of patients eligible for curative treatments and very limited survival benefits with the use of sorafenib, the current standard of care for advanced disease.

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