Macrophage recruitment by fibrocystin‐defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis

Luigi Locatelli, Massimiliano Cadamuro, Carlo Spirlì, Romina Fiorotto, Silvia Lecchi, Carola Maria Morell, Yury Popov, Roberto Scirpo, Maria De Matteis, Mariangela Amenduni, Andrea Pietrobattista, Giuliano Torre, Detlef Schuppan, Luca Fabris, Mario Strazzabosco – 8 December 2015 – Congenital hepatic fibrosis (CHF) is a disease of the biliary epithelium characterized by bile duct changes resembling ductal plate malformations and by progressive peribiliary fibrosis, in the absence of overt necroinflammation.

Acute and Chronic Hepatitis E Virus Infection in Human Immunodeficiency Virus‐Infected U.S. Women

Mark H. Kuniholm, Edgar Ong, Boris M. Hogema, Marco Koppelman, Kathryn Anastos, Marion G. Peters, Eric C. Seaberg, Yue Chen, Kenrad E. Nelson, Jeffrey M. Linnen – 8 December 2015 – Exposure to hepatitis E virus (HEV) is common in the United States, but there are few data on prevalence of HEV/human immunodeficiency virus (HIV) coinfection in U.S. populations. We tested 2,919 plasma samples collected from HIV‐infected (HIV+) women and men enrolled in U.S. cohort studies for HEV viremia using a high‐throughput nucleic acid testing (NAT) platform.

Persistence of seropositivity among persons vaccinated for hepatitis A during infancy by maternal antibody status: 15‐year follow‐up

Philip R. Spradling, Lisa R. Bulkow, Susan E. Negus, Chriss Homan, Michael G. Bruce, Brian J. McMahon – 5 December 2015 – The effect of passively transferred maternal antibody to hepatitis A virus (anti‐HAV) on the duration of seropositivity after hepatitis A vaccination during infancy and early childhood is unclear.

Portal inflammation is independently associated with fibrosis and metabolic syndrome in pediatric nonalcoholic fatty liver disease

Jake P. Mann, Rita De Vito, Antonella Mosca, Anna Alisi, Matthew J. Armstrong, Massimiliano Raponi, Ulrich Baumann, Valerio Nobili – 5 December 2015 – Pediatric nonalcoholic fatty liver disease (NAFLD) histology demonstrates variable amounts of portal inflammation, which may be associated with more severe liver disease and fibrosis. We assessed the relationship between portal inflammation, hepatic fibrosis, and the metabolic syndrome in pediatric NAFLD. Children with biopsy‐proven NAFLD were eligible for inclusion.

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