2015 Hepatology referees (volumes 61 and 62)
25 November 2015
Hepatology highlights
Jean‐François Dufour – 25 November 2015
The rs2294918 E434K variant modulates patatin‐like phospholipase domain‐containing 3 expression and liver damage
Benedetta Donati, Benedetta Maria Motta, Piero Pingitore, Marica Meroni, Alessandro Pietrelli, Anna Alisi, Salvatore Petta, Chao Xing, Paola Dongiovanni, Benedetta del Menico, Raffaela Rametta, Rosellina Margherita Mancina, Sara Badiali, Anna Ludovica Fracanzani, Antonio Craxì, Silvia Fargion, Valerio Nobili, Stefano Romeo, Luca Valenti – 25 November 2015 – The patatin‐like phosholipase domain‐containing 3 (PNPLA3) rs738409 polymorphism (I148M) is a major determinant of hepatic fat and predisposes to the full spectrum of liver damage in nonalcoholic fatty liver disease (NAFLD).
Late‐breaking abstracts
25 November 2015
The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota
Jérôme Boursier, Olaf Mueller, Matthieu Barret, Mariana Machado, Lionel Fizanne, Felix Araujo‐Perez, Cynthia D. Guy, Patrick C. Seed, John F. Rawls, Lawrence A. David, Gilles Hunault, Frédéric Oberti, Paul Calès, Anna Mae Diehl – 24 November 2015 – Several animal studies have emphasized the role of gut microbiota in nonalcoholic fatty liver disease (NAFLD). However, data about gut dysbiosis in human NAFLD remain scarce in the literature, especially studies including the whole spectrum of NAFLD lesions.
Concomitant drug‐induced liver and skin reactions: An Indian experience
Einar S. Björnsson, Jon Hjaltalin Ólafsson – 24 November 2015
De novo hepatitis b prophylaxis with hepatitis B virus vaccine and hepatitis B immunoglobulin in pediatric recipients of core antibody–positive livers
Sanghoon Lee, Jong Man Kim, Gyu Seong Choi, Jae Berm Park, Choon Hyuck David Kwon, Yon‐Ho Choe, Jae‐Won Joh, Suk‐Koo Lee – 24 November 2015 – The use of hepatitis B core antibody–positive (HBcAb+) grafts for liver transplantation (LT) has the potential to safely expand the donor pool, as long as proper prophylaxis against de novo hepatitis B (DNHB) is employed. The aim of this study was to characterize the longterm outcome of pediatric LT recipients of HBcAb+ liver grafts under a prophylaxis regimen against DNHB using hepatitis B virus (HBV) vaccine and hepatitis B immunoglobulin (HBIG).
Esophageal balloon tamponade versus esophageal stent in controlling acute refractory variceal bleeding: A multicenter randomized, controlled trial
Àngels Escorsell, Oana Pavel, Andrés Cárdenas, Rosa Morillas, Elba Llop, Càndid Villanueva, Juan C. Garcia‐Pagán, Jaime Bosch, Variceal Bleeding Study Group – 24 November 2015 – Balloon tamponade is recommended only as a “bridge” to definitive therapy in patients with cirrhosis and massive or refractory esophageal variceal bleeding (EVB), but is frequently associated with rebleeding and severe complications.