An empirical broad spectrum antibiotic therapy in health‐care–associated infections improves survival in patients with cirrhosis: A randomized trial

Manuela Merli, Cristina Lucidi, Vincenza Di Gregorio, Barbara Lattanzi, Valerio Giannelli, Michela Giusto, Alessio Farcomeni, Giancarlo Ceccarelli, Marco Falcone, Oliviero Riggio, Mario Venditti – 3 November 2015 – Early diagnosis and appropriate treatment of infections in cirrhosis are crucial because of their high morbidity and mortality. Multidrug‐resistant (MDR) infections are on the increase in health care settings. Health‐care–associated (HCA) infections are still frequently treated as community‐acquired with a detrimental effect on survival.

An empirical broad spectrum antibiotic therapy in health‐care–associated infections improves survival in patients with cirrhosis: A randomized trial

Manuela Merli, Cristina Lucidi, Vincenza Di Gregorio, Barbara Lattanzi, Valerio Giannelli, Michela Giusto, Alessio Farcomeni, Giancarlo Ceccarelli, Marco Falcone, Oliviero Riggio, Mario Venditti – 3 November 2015 – Early diagnosis and appropriate treatment of infections in cirrhosis are crucial because of their high morbidity and mortality. Multidrug‐resistant (MDR) infections are on the increase in health care settings. Health‐care–associated (HCA) infections are still frequently treated as community‐acquired with a detrimental effect on survival.

The profile of platelet α‐granule released molecules affects postoperative liver regeneration

Patrick Starlinger, Stefanie Haegele, Florian Offensperger, Lukas Oehlberger, David Pereyra, Julia B Kral, Waltraud C. Schrottmaier, Sigrun Badrnya, Thomas Reiberger, Arnulf Ferlitsch, Judith Stift, Florian Luf, Christine Brostjan, Thomas Gruenberger, Alice Assinger – 3 November 2015 – Platelets promote liver regeneration through site‐specific serotonin release from dense granules, triggering proliferative signaling in hepatocytes.

Antibiotic prophylaxis in cirrhosis: Good and bad

Javier Fernández, Puneeta Tandon, Jose Mensa, Guadalupe Garcia‐Tsao – 3 November 2015 – Patients with cirrhosis, particularly those with decompensated cirrhosis, are at increased risk of bacterial infections that may further precipitate other liver decompensations including acute‐on‐chronic liver failure. Infections constitute the main cause of death in patients with advanced cirrhosis, and strategies to prevent them are essential.

Antibiotic prophylaxis in cirrhosis: Good and bad

Javier Fernández, Puneeta Tandon, Jose Mensa, Guadalupe Garcia‐Tsao – 3 November 2015 – Patients with cirrhosis, particularly those with decompensated cirrhosis, are at increased risk of bacterial infections that may further precipitate other liver decompensations including acute‐on‐chronic liver failure. Infections constitute the main cause of death in patients with advanced cirrhosis, and strategies to prevent them are essential.

The distribution of hepatitis B virus exposure and infection in a population‐based sample of U.S. Hispanic adults

Molly Jung, Mark H. Kuniholm, Gloria Y.F. Ho, Scott Cotler, Howard D. Strickler, Bharat Thyagarajan, Marston Youngblood, Robert C. Kaplan, Julia del Amo – 2 November 2015 – Little is known regarding the prevalence and distribution of hepatitis B virus (HBV) infection in U.S. Hispanics/Latinos. We sought to determine the prevalence of HBV exposure (serum HBV core antibody; anti‐HBc), active HBV infection (serum HBV surface antigen; HBsAg), and vaccine‐induced HBV immunity (antibody against HBV surface antigen; anti‐HBs) in U.S.

The hepatic, biliary, and pancreatic network of stem/progenitor cell niches in humans: A new reference frame for disease and regeneration

Giacomo Lanzoni, Vincenzo Cardinale, Guido Carpino – 2 November 2015 – Stem/progenitors for liver, biliary tree, and pancreas exist at early stages of development in the definitive ventral endoderm forming the foregut. In humans, they persist postnatally as part of a network, with evidence supporting their contributions to hepatic and pancreatic organogenesis throughout life. Multiple stem cell niches persist in specific anatomical locations within the human biliary tree and pancreatic ducts.

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