Cost‐effectiveness of new antiviral regimens for treatment‐naïve U.S. veterans with hepatitis C

Alexis P. Chidi, Shari Rogal, Cindy L. Bryce, Michael J. Fine, Chester B. Good, Larissa Myaskovsky, Vinod K. Rustgi, Allan Tsung, Kenneth J. Smith – 2 November 2015 – Recently approved, interferon‐free medication regimens for treating hepatitis C are highly effective, but extremely costly. We aimed to identify cost‐effective strategies for managing treatment‐naïve U.S. veterans with new hepatitis C medication regimens. We developed a Markov model with 1‐year cycle length for a cohort of 60‐year‐old veterans with untreated genotype 1 hepatitis C seeking treatment in a typical year.

Interferon‐free therapy for genotype 1 hepatitis C in liver transplant recipients: Real‐world experience from the hepatitis C therapeutic registry and research network

Robert S. Brown, Jacqueline G. O'Leary, K. Rajender Reddy, Alexander Kuo, Giuseppe J. Morelli, James R. Burton, R. Todd Stravitz, Christine Durand, Adrian M. Bisceglie, Paul Kwo, Catherine T. Frenette, Thomas G. Stewart, David R. Nelson, Michael W. Fried, Norah A. Terrault, on behalf of the Hepatitis C Therapeutic Registry Research Network Study Group – 31 October 2015 – Recurrent infection with the hepatitis C virus (HCV) after liver transplantation (LT) is associated with decreased graft and patient survival.

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Mattias Ekstedt, Hannes Hagström, Patrik Nasr, Mats Fredrikson, Per Stal, Stergios Kechagias, Rolf Hultcrantz – 30 October 2015

DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection

Maria Antonella Burza, Benedetta Maria Motta, Rosellina Margherita Mancina, Piero Pingitore, Carlo Pirazzi, Saverio Massimo Lepore, Rocco Spagnuolo, Patrizia Doldo, Cristina Russo, Veronica Lazzaro, Janett Fischer, Thomas Berg, Alessio Aghemo, Cristina Cheroni, Raffaele De Francesco, Silvia Fargion, Massimo Colombo, Christian Datz, Felix Stickel, Luca Valenti, Stefano Romeo – 30 October 2015 – Chronic hepatitis C virus (HCV) infection may progress to cirrhosis and hepatocellular carcinoma (HCC).

Categorization of drugs implicated in causing liver injury: Critical assessment based on published case reports

Einar S. Björnsson, Jay H. Hoofnagle – 30 October 2015 – An important element in assessing causality in drug‐induced liver injury is whether the implicated agent is known to cause hepatotoxicity. We classified drugs into categories based on the number of published reports of convincingly documented, clinically apparent, idiosyncratic liver injury. Drugs described in the website LiverTox (http://livertox.nih.gov) were classified into five categories based on the number of published cases (category A, ≥50; category B, 12‐49; category C, 4‐11; category D, 1‐3; category E, none).

Functional decline in patients with cirrhosis awaiting liver transplantation: Results from the functional assessment in liver transplantation (FrAILT) study

Jennifer C. Lai, Jennifer L. Dodge, Saunak Sen, Kenneth Covinsky, Sandy Feng – 30 October 2015 – Cirrhosis is characterized by sarcopenia and malnutrition, leading to progressive functional decline. We aimed to objectively measure functional decline in patients with cirrhosis awaiting liver transplantation and its association with waiting list mortality.

Human immunodeficiency virus infection does not worsen prognosis of liver transplantation for hepatocellular carcinoma

Fernando Agüero, Alejandro Forner, Christian Manzardo, Andres Valdivieso, Marino Blanes, Rafael Barcena, Antoni Rafecas, Lluis Castells, Manuel Abradelo, Julian Torre‐Cisneros, Luisa Gonzalez‐Dieguez, Magdalena Salcedo, Trinidad Serrano, Miguel Jimenez‐Perez, Jose Ignacio Herrero, Mikel Gastaca, Victoria Aguilera, Juan Fabregat, Santos del Campo, Itxarone Bilbao, Carlos Jimenez Romero, Asuncion Moreno, Antoni Rimola, Jose M.

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