A functional classification of ABCB4 variations causing progressive familial intrahepatic cholestasis type 3

Jean‐Louis Delaunay, Anne‐Marie Durand‐Schneider, Claire Dossier, Thomas Falguières, Julien Gautherot, Anne Davit‐Spraul, Tounsia Aït‐Slimane, Chantal Housset, Emmanuel Jacquemin, Michèle Maurice – 17 October 2015 – Progressive familial intrahepatic cholestasis type 3 is caused by biallelic variations of ABCB4, most often (≥70%) missense. In this study, we examined the effects of 12 missense variations identified in progressive familial intrahepatic cholestasis type 3 patients.

Treatment of hepatitis C virus–associated mixed cryoglobulinemia with direct‐acting antiviral agents

Meghan E. Sise, Allyson K. Bloom, Jessica Wisocky, Ming V. Lin, Jenna L. Gustafson, Andrew L. Lundquist, David Steele, Michael Thiim, Winfred W. Williams, Nikroo Hashemi, Arthur Y. Kim, Ravi Thadhani, Raymond T. Chung – 17 October 2015 – Hepatitis C virus (HCV) is the most common cause of mixed cryoglobulinemia syndrome (MCS). The efficacy and safety of all‐oral direct‐acting antiviral (DAA) therapy in HCV‐associated MCS (HCV‐MCS) is largely unknown.

Regulation of mechanosensitive biliary epithelial transport by the epithelial Na+ channel

Qin Li, Charles Kresge, Abhijit Bugde, Michelle Lamphere, Jason Y. Park, Andrew P. Feranchak – 17 October 2015 – Intrahepatic biliary epithelial cells (BECs), also known as cholangiocytes, modulate the volume and composition of bile through the regulation of secretion and absorption. While mechanosensitive Cl– efflux has been identified as an important secretory pathway, the counterabsorptive pathways have not been identified.

Chronic hepatitis C viral infection subverts vaccine‐induced T‐cell immunity in humans

Christabel Kelly, Leo Swadling, Stefania Capone, Anthony Brown, Rachel Richardson, John Halliday, Annette von Delft, Ye Oo, David Mutimer, Ayako Kurioka, Felicity Hartnell, Jane Collier, Virginia Ammendola, Mariarosaria Del Sorbo, Fabiana Grazioli, Maria Luisa Esposito, Stefania Di Marco, Loredana Siani, Cinzia Traboni, Adrian V.S.

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