Reply
Koji Miyanishi, Masayoshi Kobune, Junji Kato – 16 October 2015
Continued controversy over the safety of beta‐blockers in decompensated cirrhosis
Agustín Albillos, Javier Martínez, Luis Téllez – 16 October 2015
No scientific basis to restrict 8 weeks of treatment with ledipasvir/sofosbuvir to patients with hepatitis C virus RNA <6,000,000 IU/mL
Thomas R. O'Brien, Jordan J. Feld, Shyam Kottilil, Ruth M. Pfeiffer – 16 October 2015
Chronic hepatitis C viral infection subverts vaccine‐induced T‐cell immunity in humans
Christabel Kelly, Leo Swadling, Stefania Capone, Anthony Brown, Rachel Richardson, John Halliday, Annette von Delft, Ye Oo, David Mutimer, Ayako Kurioka, Felicity Hartnell, Jane Collier, Virginia Ammendola, Mariarosaria Del Sorbo, Fabiana Grazioli, Maria Luisa Esposito, Stefania Di Marco, Loredana Siani, Cinzia Traboni, Adrian V.S.
What have we learned about intrahepatic cholestasis of pregnancy?
Humberto Reyes – 16 October 2015
Transfusing common sense instead of blood products into coagulation testing in patients with cirrhosis: Overtreatment ≠ safety
Robert S. Rahimi, Jacqueline G. O'Leary – 16 October 2015
Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase
Se‐Hyuk Kim, Yoon Jeon, Hyun‐Soo Kim, Jin‐Kwan Lee, Han Jeong Lim, Donglim Kang, Hyeseong Cho, Cheol‐Keun Park, Ho Lee, Chang‐Woo Lee – 12 October 2015 – Hepatocyte chromosome polyploidization is an important feature of liver development and seems to be required for response to liver stress and injury signals. However, the question of how polyploidization can be tightly regulated in liver growth remains to be answered. Using a conditional knockout mouse model, liver‐specific depletion of Ssu72 protein phosphatase was found to result in impairment in regulation of polyploidization.
Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study
Martina Goffredo, Sonia Caprio, Ariel E. Feldstein, Ebe D'Adamo, Melissa M. Shaw, Bridget Pierpont, Mary Savoye, Hongyu Zhao, Allen E. Bale, Nicola Santoro – 12 October 2015 – We assessed the association between the single‐nucleotide polymorphism (SNP) rs58542926 in the transmembrane 6 superfamily member 2 (TM6SF2) gene and fatty liver disease in obese youth. We genotyped the TM6SF2 rs58542926 SNP in a multiethnic cohort of 957 obese children and adolescents (42% Caucasians, 28% African Americans, 30% Hispanics).
Indoleamine‐2,3‐dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B
Sachiyo Yoshio, Masaya Sugiyama, Hirotaka Shoji, Yohei Mano, Eiji Mita, Toru Okamoto, Yoshiharu Matsuura, Alato Okuno, Osamu Takikawa, Masashi Mizokami, Tatsuya Kanto – 12 October 2015 – Indoleamine‐2, 3‐dioxygenase (IDO), an interferon‐γ‐inducible enzyme catalyzing tryptophan into kynurenine, exerts dual functions in infectious diseases, acting as a suppressor of intracellular pathogens and as an immune regulator. We explored the roles of IDO in hepatitis B virus (HBV) clearance from infected patients.
Liver capsule: Age‐influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man
Jean Publicover, Jillian M. Jespersen, Audra J. Johnson, Stephen L. Nishimura, Amanda Goodsell, Adil E. Wakil, Philip Rosenthal, Eric Pai, Lia Avanesyan, Stewart Cooper, Jody L. Baron – 12 October 2015