Kwang Hwa Jung, Jing Zhang, Chong Zhou, Hong Shen, Mihai Gagea, Cristian Rodriguez‐Aguayo, Gabriel Lopez‐Berestein, Anil K. Sood, Laura Beretta – 24 November 2015 – The death rate from hepatocellular carcinoma (HCC) is increasing, and liver cancer is the second leading cause of cancer‐related mortality worldwide. Most patients with HCC have underlying liver cirrhosis and compromised liver function, limiting treatment options. Cirrhosis is associated with cell dedifferentiation and expansion of hepatocholangiolar progenitor cells.

Jérôme Boursier, Olaf Mueller, Matthieu Barret, Mariana Machado, Lionel Fizanne, Felix Araujo‐Perez, Cynthia D. Guy, Patrick C. Seed, John F. Rawls, Lawrence A. David, Gilles Hunault, Frédéric Oberti, Paul Calès, Anna Mae Diehl – 24 November 2015 – Several animal studies have emphasized the role of gut microbiota in nonalcoholic fatty liver disease (NAFLD). However, data about gut dysbiosis in human NAFLD remain scarce in the literature, especially studies including the whole spectrum of NAFLD lesions.

Fabio Piscaglia, Gianluca Svegliati‐Baroni, Andrea Barchetti, Anna Pecorelli, Sara Marinelli, Claudio Tiribelli, Stefano Bellentani, HCC‐NAFLD Italian Study Group – 24 November 2015 – Nonalcoholic fatty liver disease (NAFLD) represents the hepatic manifestation of metabolic syndrome and may evolve into hepatocellular carcinoma (HCC). Only scanty clinical information is available on HCC in NAFLD.

Lars C. Pietersen, A. Claire Dulk, Andries E. Braat, Hein Putter, Kerem Sebib Korkmaz, Andre G. Baranski, Alexander F. M. Schaapherder, Jeroen Dubbeld, Bart Hoek, Jan Ringers – 24 November 2015 – The aim of the present study was to assess whether flushing the donor liver with urokinase immediately before implantation reduces the incidence of nonanastomotic biliary strictures (NASs) after liver transplantation, without causing increased blood loss, analyzed as a historical cohort study. Between January 2005 and October 2012, all liver (re‐)transplantations were included.

Sven Pischke, Johannes Hartl, Anne‐Marie Roque‐Afonso, Vincent Mallet – 24 November 2015

Gideon M. Hirschfield, M. Eric Gershwin, Richard Strauss, Marlyn J. Mayo, Cynthia Levy, Bin Zou, Jewel Johanns, Ivo P. Nnane, Bidisha Dasgupta, Katherine Li, Carlo Selmi, Hanns‐Ulrich Marschall, David Jones, Keith Lindor, PURIFI Study Group – 24 November 2015 – The interleukin (IL)‐12 signaling cascade has been associated with primary biliary cholangitis (PBC).

Yohei Misumi, Yasuko Narita, Toshinori Oshima, Mitsuharu Ueda, Taro Yamashita, Masayoshi Tasaki, Konen Obayashi, Kaori Isono, Yukihiro Inomata, Yukio Ando – 24 November 2015 – Domino liver transplantation (DLT) with liver grafts from patients with hereditary transthyretin (TTR) amyloidosis has been performed throughout the world because of a severe liver graft shortage. Reports of acquired systemic TTR amyloidosis in domino liver recipients have been increasing; however, the precise pathogenesis and clinical course of acquired TTR amyloidosis remains unclear.

Lars Bossen, Aleksander Krag, Hendrik Vilstrup, Hugh Watson, Peter Jepsen – 24 November 2015 – The safety of nonselective β‐blockers (NSBBs) in advanced cirrhosis has been questioned. We used data from three satavaptan trials to examine whether NSBBs increase mortality in cirrhosis patients with ascites. The trials were conducted in 2006‐2008 and included 1198 cirrhosis patients with ascites followed for 1 year.

John R. Senior – 24 November 2015

Shridhar Vasantrao Sasturkar, Paul David, Shreya Sharma, Shiv Kumar Sarin, Nirupama Trehanpati, Viniyendra Pamecha – 24 November 2015 – Cytokines and growth factors have prominent roles in liver regeneration. The aim of this study was to evaluate the biological markers of liver regeneration in healthy donors undergoing right lobe donor hepatectomy for living donor liver transplantation. Twenty‐five voluntary liver donors were enrolled. Peripheral blood samples were taken a day before the operation and on postoperative days (PODs) 1, 3, 7, 14, and 42.