Bidirectional transendothelial migration of monocytes across hepatic sinusoidal endothelium shapes monocyte differentiation and regulates the balance between immunity and tolerance in liver

Henning W. Zimmermann, Tony Bruns, Chris J. Weston, Stuart M. Curbishley, Evaggelia Liaskou, Ka‐Kit Li, Yazid J. Resheq, Paul W. Badenhorst, David H. Adams – 16 October 2015 – Monocytes are versatile cells that can fulfill proinflammatory and anti‐inflammatory functions when recruited to the liver. Recruited monocytes differentiate into tissue macrophages and dendritic cells, which sample antigens and migrate to lymph nodes to elicit T‐cell responses.

Peripheral insulin resistance predicts liver damage in nondiabetic subjects with nonalcoholic fatty liver disease

Chiara Rosso, Lavinia Mezzabotta, Melania Gaggini, Federico Salomone, Roberto Gambino, Andrea Marengo, Francesca Saba, Ester Vanni, Ramy Younes, Chiara Saponaro, Emma Buzzigoli, Gian Paolo Caviglia, Maria Lorena Abate, Antonina Smedile, Mario Rizzetto, Maurizio Cassader, Amalia Gastaldelli, Elisabetta Bugianesi – 16 October 2015 – Surrogate indexes of insulin resistance and insulin sensitivity are widely used in nonalcoholic fatty liver disease (NAFLD), although they have never been validated in this population.

Chronic hepatitis C viral infection subverts vaccine‐induced T‐cell immunity in humans

Christabel Kelly, Leo Swadling, Stefania Capone, Anthony Brown, Rachel Richardson, John Halliday, Annette von Delft, Ye Oo, David Mutimer, Ayako Kurioka, Felicity Hartnell, Jane Collier, Virginia Ammendola, Mariarosaria Del Sorbo, Fabiana Grazioli, Maria Luisa Esposito, Stefania Di Marco, Loredana Siani, Cinzia Traboni, Adrian V.S.

Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase

Se‐Hyuk Kim, Yoon Jeon, Hyun‐Soo Kim, Jin‐Kwan Lee, Han Jeong Lim, Donglim Kang, Hyeseong Cho, Cheol‐Keun Park, Ho Lee, Chang‐Woo Lee – 12 October 2015 – Hepatocyte chromosome polyploidization is an important feature of liver development and seems to be required for response to liver stress and injury signals. However, the question of how polyploidization can be tightly regulated in liver growth remains to be answered. Using a conditional knockout mouse model, liver‐specific depletion of Ssu72 protein phosphatase was found to result in impairment in regulation of polyploidization.

Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study

Martina Goffredo, Sonia Caprio, Ariel E. Feldstein, Ebe D'Adamo, Melissa M. Shaw, Bridget Pierpont, Mary Savoye, Hongyu Zhao, Allen E. Bale, Nicola Santoro – 12 October 2015 – We assessed the association between the single‐nucleotide polymorphism (SNP) rs58542926 in the transmembrane 6 superfamily member 2 (TM6SF2) gene and fatty liver disease in obese youth. We genotyped the TM6SF2 rs58542926 SNP in a multiethnic cohort of 957 obese children and adolescents (42% Caucasians, 28% African Americans, 30% Hispanics).

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