Up‐regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis

Chun‐Ming Wong, Lai Wei, Cheuk‐Ting Law, Daniel Wai‐Hung Ho, Felice Ho‐Ching Tsang, Sandy Leung‐Kuen Au, Karen Man‐Fong Sze, Joyce Man‐Fong Lee, Carmen Chak‐Lui Wong, Irene Oi‐Lin Ng – 20 October 2015 – Epigenetic deregulation plays an important role in liver carcinogenesis. Using transcriptome sequencing, we examined the expression of 591 epigenetic regulators in hepatitis B‐associated human hepatocellular carcinoma (HCC). We found that aberrant expression of epigenetic regulators was a common event in HCC.

Costs and consequences: Hepatitis C seroprevalence in the military and its impact on potential screening strategies

David M. Brett‐Major, Kevin D. Frick, Jennifer A. Malia, Shilpa Hakre, Jason F. Okulicz, Charmagne G. Beckett, Linda L. Jagodinski, Michael A. Forgione, Philip L. Gould, Stephen A. Harrison, Clinton K. Murray, Francisco J. Rentas, Adam W. Armstrong, Aatif M. Hayat, Laura A. Pacha, Peter Dawson, Angelia A. Eick‐Cost, Hala H. Maktabi, Nelson L. Michael, Steven B. Cersovsky, Sheila A. Peel, Paul T. Scott – 20 October 2015 – Knowledge of the contemporary epidemiology of hepatitis C viral (HCV) infection among military personnel can inform potential Department of Defense screening policy.

Longterm outcomes of auxiliary partial orthotopic liver transplantation in preadolescent children with fulminant hepatic failure

Joshua Weiner, Adam Griesemer, Eddie Island, Steven Lobritto, Mercedes Martinez, Gennaro Selvaggi, Jay Lefkowitch, Monica Velasco, Panagiotis Tryphonopoulos, Jean Emond, Andreas Tzakis, Tomoaki Kato – 19 October 2015 – By preserving part of the native liver, auxiliary partial orthotopic liver transplantation (APOLT) provides the advantage of potential immunosuppression (ISP) withdrawal if the native liver recovers but has had limited acceptance, especially in the United States, due to technical complications and low rates of native liver regeneration.

Interleukin 18 binding protein ameliorates ischemia/reperfusion–induced hepatic injury in mice

Nikolaos Ouzounidis, Alexandros Giakoustidis, Theofilos Poutahidis, Katerina Angelopoulou, Stavros Iliadis, Antonis Chatzigiagkos, Argyro Zacharioudaki, Stamatis Angelopoulos, Apostolos Papalois, Vasilios Papanikolaou, Dimitrios Giakoustidis – 19 October 2015 – Inflammation‐associated oxidative stress contributes to hepatic ischemia/reperfusion injury (IRI). Detrimental inflammatory event cascades largely depend on activated Kupffer cells (KCs) and neutrophils, as well as proinflammatory cytokines, including tumor necrosis factor α (TNF‐α) and interleukin (IL) 18.

Intention to treat outcome of T1 hepatocellular carcinoma with the “wait and not ablate” approach until meeting T2 criteria for liver transplant listing

Neil Mehta, Monika Sarkar, Jennifer L. Dodge, Nicholas Fidelman, John P. Roberts, Francis Y. Yao – 19 October 2015 – Patients with T1 hepatocellular carcinoma (HCC; 1 lesion < 2 cm) are currently not eligible for priority listing for liver transplantation (LT). A common practice is to wait without locoregional therapy (LRT) until tumor growth occurs from T1 to T2 (1 lesion 2‐5 cm or 2‐3 lesions ≤ 3 cm) to be eligible for listing with Model for End‐Stage Liver Disease exception.

Treatment of hepatitis C virus–associated mixed cryoglobulinemia with direct‐acting antiviral agents

Meghan E. Sise, Allyson K. Bloom, Jessica Wisocky, Ming V. Lin, Jenna L. Gustafson, Andrew L. Lundquist, David Steele, Michael Thiim, Winfred W. Williams, Nikroo Hashemi, Arthur Y. Kim, Ravi Thadhani, Raymond T. Chung – 17 October 2015 – Hepatitis C virus (HCV) is the most common cause of mixed cryoglobulinemia syndrome (MCS). The efficacy and safety of all‐oral direct‐acting antiviral (DAA) therapy in HCV‐associated MCS (HCV‐MCS) is largely unknown.

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