Chun‐Ming Wong, Lai Wei, Cheuk‐Ting Law, Daniel Wai‐Hung Ho, Felice Ho‐Ching Tsang, Sandy Leung‐Kuen Au, Karen Man‐Fong Sze, Joyce Man‐Fong Lee, Carmen Chak‐Lui Wong, Irene Oi‐Lin Ng – 20 October 2015 – Epigenetic deregulation plays an important role in liver carcinogenesis. Using transcriptome sequencing, we examined the expression of 591 epigenetic regulators in hepatitis B‐associated human hepatocellular carcinoma (HCC). We found that aberrant expression of epigenetic regulators was a common event in HCC.

Jean‐François Dufour – 20 October 2015

Jean‐François Dufour – 20 October 2015

Neil Mehta, Monika Sarkar, Jennifer L. Dodge, Nicholas Fidelman, John P. Roberts, Francis Y. Yao – 19 October 2015 – Patients with T1 hepatocellular carcinoma (HCC; 1 lesion < 2 cm) are currently not eligible for priority listing for liver transplantation (LT). A common practice is to wait without locoregional therapy (LRT) until tumor growth occurs from T1 to T2 (1 lesion 2‐5 cm or 2‐3 lesions ≤ 3 cm) to be eligible for listing with Model for End‐Stage Liver Disease exception.

Nikolaos Ouzounidis, Alexandros Giakoustidis, Theofilos Poutahidis, Katerina Angelopoulou, Stavros Iliadis, Antonis Chatzigiagkos, Argyro Zacharioudaki, Stamatis Angelopoulos, Apostolos Papalois, Vasilios Papanikolaou, Dimitrios Giakoustidis – 19 October 2015 – Inflammation‐associated oxidative stress contributes to hepatic ischemia/reperfusion injury (IRI). Detrimental inflammatory event cascades largely depend on activated Kupffer cells (KCs) and neutrophils, as well as proinflammatory cytokines, including tumor necrosis factor α (TNF‐α) and interleukin (IL) 18.

Joshua Weiner, Adam Griesemer, Eddie Island, Steven Lobritto, Mercedes Martinez, Gennaro Selvaggi, Jay Lefkowitch, Monica Velasco, Panagiotis Tryphonopoulos, Jean Emond, Andreas Tzakis, Tomoaki Kato – 19 October 2015 – By preserving part of the native liver, auxiliary partial orthotopic liver transplantation (APOLT) provides the advantage of potential immunosuppression (ISP) withdrawal if the native liver recovers but has had limited acceptance, especially in the United States, due to technical complications and low rates of native liver regeneration.

Neil Rajoriya, Joanna A Leithead, Ahmed M Elsharkawy, Bridget K Gunson, Thamara M Perera, David Mutimer – 19 October 2015

Marc Ruivard, Fabrice Laine, Yves Deugnier – 17 October 2015

Qin Li, Charles Kresge, Abhijit Bugde, Michelle Lamphere, Jason Y. Park, Andrew P. Feranchak – 17 October 2015 – Intrahepatic biliary epithelial cells (BECs), also known as cholangiocytes, modulate the volume and composition of bile through the regulation of secretion and absorption. While mechanosensitive Cl– efflux has been identified as an important secretory pathway, the counterabsorptive pathways have not been identified.

Meghan E. Sise, Allyson K. Bloom, Jessica Wisocky, Ming V. Lin, Jenna L. Gustafson, Andrew L. Lundquist, David Steele, Michael Thiim, Winfred W. Williams, Nikroo Hashemi, Arthur Y. Kim, Ravi Thadhani, Raymond T. Chung – 17 October 2015 – Hepatitis C virus (HCV) is the most common cause of mixed cryoglobulinemia syndrome (MCS). The efficacy and safety of all‐oral direct‐acting antiviral (DAA) therapy in HCV‐associated MCS (HCV‐MCS) is largely unknown.