Functional decline in patients with cirrhosis awaiting liver transplantation: Results from the functional assessment in liver transplantation (FrAILT) study

Jennifer C. Lai, Jennifer L. Dodge, Saunak Sen, Kenneth Covinsky, Sandy Feng – 30 October 2015 – Cirrhosis is characterized by sarcopenia and malnutrition, leading to progressive functional decline. We aimed to objectively measure functional decline in patients with cirrhosis awaiting liver transplantation and its association with waiting list mortality.

Categorization of drugs implicated in causing liver injury: Critical assessment based on published case reports

Einar S. Björnsson, Jay H. Hoofnagle – 30 October 2015 – An important element in assessing causality in drug‐induced liver injury is whether the implicated agent is known to cause hepatotoxicity. We classified drugs into categories based on the number of published reports of convincingly documented, clinically apparent, idiosyncratic liver injury. Drugs described in the website LiverTox (http://livertox.nih.gov) were classified into five categories based on the number of published cases (category A, ≥50; category B, 12‐49; category C, 4‐11; category D, 1‐3; category E, none).

DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection

Maria Antonella Burza, Benedetta Maria Motta, Rosellina Margherita Mancina, Piero Pingitore, Carlo Pirazzi, Saverio Massimo Lepore, Rocco Spagnuolo, Patrizia Doldo, Cristina Russo, Veronica Lazzaro, Janett Fischer, Thomas Berg, Alessio Aghemo, Cristina Cheroni, Raffaele De Francesco, Silvia Fargion, Massimo Colombo, Christian Datz, Felix Stickel, Luca Valenti, Stefano Romeo – 30 October 2015 – Chronic hepatitis C virus (HCV) infection may progress to cirrhosis and hepatocellular carcinoma (HCC).

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Mattias Ekstedt, Hannes Hagström, Patrik Nasr, Mats Fredrikson, Per Stal, Stergios Kechagias, Rolf Hultcrantz – 30 October 2015

Efficacy and cost‐effectiveness of voriconazole prophylaxis for prevention of invasive aspergillosis in high‐risk liver transplant recipients

Julius Balogh, Sherilyn Gordon Burroughs, Maha Boktour, Samir Patel, Ashish Saharia, Robert A. Ochoa, Robert McFadden, David W. Victor, Victor Ankoma‐Sey, Joseph Galati, Howard P. Monsour, Victor Fainstein, Xian C. Li, Kevin A. Grimes, A. Osama Gaber, Thomas Aloia, R. Mark Ghobrial – 29 October 2015 – Aspergillus infection remains a significant and deadly complication after liver transplantation (LT).

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