Covered transjugular intrahepatic portosystemic shunt versus endoscopic therapy + β‐blocker for prevention of variceal rebleeding

I. Lisanne Holster, Eric T.T.L. Tjwa, Adriaan Moelker, Alexandra Wils, Bettina E. Hansen, J. Reinoud Vermeijden, Pieter Scholten, Bart van Hoek, Jan J. Nicolai, Ernst J. Kuipers, Peter M.T. Pattynama, Henk R. van Buuren – 30 October 2015 – Gastroesophageal variceal bleeding in patients with cirrhosis is associated with significant morbidity and mortality, as well as a high rebleeding risk. Limited data are available on the role of transjugular intrahepatic portosystemic shunt (TIPS) with covered stents in patients receiving standard endoscopic, vasoactive, and antibiotic treatment.

Bile salt export pump‐reactive antibodies form a polyclonal, multi‐inhibitory response in antibody‐induced bile salt export pump deficiency

Jan Stindt, Stefanie Kluge, Carola Dröge, Verena Keitel, Claudia Stross, Ulrich Baumann, Florian Brinkert, Anil Dhawan, Guido Engelmann, Rainer Ganschow, Patrick Gerner, Enke Grabhorn, A. S. Knisely, Khalid A. Noli, Ieva Pukite, Ross W. Shepherd, Takehisa Ueno, Lutz Schmitt, Constanze Wiek, Helmut Hanenberg, Dieter Häussinger, Ralf Kubitz – 30 October 2015 – Progressive familial intrahepatic cholestasis type 2 (PFIC‐2) is caused by mutations in ABCB11, encoding the bile salt export pump (BSEP).

Human immunodeficiency virus infection does not worsen prognosis of liver transplantation for hepatocellular carcinoma

Fernando Agüero, Alejandro Forner, Christian Manzardo, Andres Valdivieso, Marino Blanes, Rafael Barcena, Antoni Rafecas, Lluis Castells, Manuel Abradelo, Julian Torre‐Cisneros, Luisa Gonzalez‐Dieguez, Magdalena Salcedo, Trinidad Serrano, Miguel Jimenez‐Perez, Jose Ignacio Herrero, Mikel Gastaca, Victoria Aguilera, Juan Fabregat, Santos del Campo, Itxarone Bilbao, Carlos Jimenez Romero, Asuncion Moreno, Antoni Rimola, Jose M.

Persistent hepatitis C viral replication despite priming of functional CD8+ T cells by combined therapy with a vaccine and a direct‐acting antiviral

Benoit Callendret, Heather B. Eccleston, William Satterfield, Stefania Capone, Antonella Folgori, Riccardo Cortese, Alfredo Nicosia, Christopher M. Walker – 29 October 2015 – Exhaustion of antiviral CD8+ T cells contributes to persistence of hepatitis C viral (HCV) infection. This immune response has proved difficult to restore by therapeutic vaccination, even when HCV replication is suppressed using antiviral regimens containing type I interferon.

Persistent hepatitis C viral replication despite priming of functional CD8+ T cells by combined therapy with a vaccine and a direct‐acting antiviral

Benoit Callendret, Heather B. Eccleston, William Satterfield, Stefania Capone, Antonella Folgori, Riccardo Cortese, Alfredo Nicosia, Christopher M. Walker – 29 October 2015 – Exhaustion of antiviral CD8+ T cells contributes to persistence of hepatitis C viral (HCV) infection. This immune response has proved difficult to restore by therapeutic vaccination, even when HCV replication is suppressed using antiviral regimens containing type I interferon.

Efficacy and cost‐effectiveness of voriconazole prophylaxis for prevention of invasive aspergillosis in high‐risk liver transplant recipients

Julius Balogh, Sherilyn Gordon Burroughs, Maha Boktour, Samir Patel, Ashish Saharia, Robert A. Ochoa, Robert McFadden, David W. Victor, Victor Ankoma‐Sey, Joseph Galati, Howard P. Monsour, Victor Fainstein, Xian C. Li, Kevin A. Grimes, A. Osama Gaber, Thomas Aloia, R. Mark Ghobrial – 29 October 2015 – Aspergillus infection remains a significant and deadly complication after liver transplantation (LT).

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