Serial changes of cytokines and growth factors in peripheral circulation after right lobe donor hepatectomy

Shridhar Vasantrao Sasturkar, Paul David, Shreya Sharma, Shiv Kumar Sarin, Nirupama Trehanpati, Viniyendra Pamecha – 24 November 2015 – Cytokines and growth factors have prominent roles in liver regeneration. The aim of this study was to evaluate the biological markers of liver regeneration in healthy donors undergoing right lobe donor hepatectomy for living donor liver transplantation. Twenty‐five voluntary liver donors were enrolled. Peripheral blood samples were taken a day before the operation and on postoperative days (PODs) 1, 3, 7, 14, and 42.

PI3K/AKT/mTOR‐dependent stabilization of oncogenic far‐upstream element binding proteins in hepatocellular carcinoma cells

Jana Samarin, Vibor Laketa, Mona Malz, Stephanie Roessler, Ilan Stein, Elad Horwitz, Stephan Singer, Eleni Dimou, Antonio Cigliano, Michaela Bissinger, Christine Susanne Falk, Xin Chen, Steven Dooley, Eli Pikarsky, Diego Francesco Calvisi, Carsten Schultz, Peter Schirmacher, Kai Breuhahn – 24 November 2015 – Transcription factors of the far‐upstream element‐binding protein (FBP) family represent cellular pathway hubs, and their overexpression in liver cancer (hepatocellular carcinoma [HCC]) stimulates tumor cell proliferation and correlates with poor prognosis.

The neuroimmune guidance cue netrin‐1 controls resolution programs and promotes liver regeneration

Martin Schlegel, David Köhler, Andreas Körner, Tiago Granja, Andreas Straub, Martin Giera, Valbona Mirakaj – 17 November 2015 – Hepatic ischemia/reperfusion (I/R) is a major adverse reaction to liver transplantation, hemorrhagic shock, or resection. Recently, the anti‐inflammatory properties of the axonal guidance cue netrin‐1 were reported. Here, we demonstrate that netrin‐1 also impacts the resolution of inflammation and promotes hepatic repair and regeneration during liver I/R injury.

Antiviral therapy for chronic hepatitis B viral infection in adults: A systematic review and meta‐analysis

Anna S.F. Lok, Brian J. McMahon, Robert S. Brown, John B. Wong, Ahmed T. Ahmed, Wigdan Farah, Jehad Almasri, Fares Alahdab, Khalid Benkhadra, Mohamed A. Mouchli, Siddharth Singh, Essa A. Mohamed, Abd Moain Abu Dabrh, Larry J. Prokop, Zhen Wang, Mohammad Hassan Murad, Khaled Mohammed – 13 November 2015 – Chronic hepatitis B viral (HBV) infection remains a significant global health problem. Evidence‐based guidelines are needed to help providers determine when treatment should be initiated, which medication is most appropriate, and when treatment can safely be stopped.

Antiviral therapy in management of chronic hepatitis B viral infection in children: A systematic review and meta‐analysis

Maureen M. Jonas, Anna S.F. Lok, Brian J. McMahon, Robert S. Brown, John B. Wong, Ahmed T. Ahmed, Wigdan Farah, Mohamed A. Mouchli, Siddharth Singh, Larry J. Prokop, Mohammad Hassan Murad, Khaled Mohammed – 13 November 2015 – Most individuals with chronic hepatitis B viral (HBV) infection acquired the infection around the time of birth or during early childhood. We aimed to synthesize evidence regarding the effectiveness of antiviral therapy in the management of chronic HBV infection in children.

Subscribe to