Genetic variation in STAT4 predicts response to interferon‐α therapy for hepatitis B e antigen‐positive chronic hepatitis B

De‐Ke Jiang, Xiaopan Wu, Ji Qian, Xiao‐Pin Ma, Jingmin Yang, Zhuo Li, Runhua Wang, Li Sun, Fang Liu, Pengyin Zhang, Xilin Zhu, Jia Wu, Kangmei Chen, Carly Conran, S. Lilly Zheng, Daru Lu, Long Yu, Ying Liu, Jianfeng Xu – 24 December 2015 – Interferon (IFN)‐α is a first‐line therapy for chronic hepatitis B (CHB) patients but only initiates a response in a minority of patients. A genetic variant, rs7574865 in STAT4, was recently reported to be associated with risk of developing CHB and hepatitis B virus‐related hepatocellular carcinoma.

Acetyl‐coenzyme A carboxylase alpha promotion of glucose‐mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients

Ming‐Da Wang, Han Wu, Gong‐Bo Fu, Hui‐Lu Zhang, Xu Zhou, Liang Tang, Li‐Wei Dong, Chen‐Jie Qin, Shuai Huang, Ling‐Hao Zhao, Min Zeng, Meng‐Chao Wu, He‐Xin Yan, Hong‐Yang Wang – 23 December 2015 – Solid tumors often suffer from suboptimal oxygen and nutrient supplies. This stress underlies the requirement for metabolic adaptation. Aberrantly activated de novo lipogenesis is critical for development and progression of human hepatocellular carcinoma (HCC).

Weight loss results in significant improvements in quality of life for patients with nonalcoholic fatty liver disease: A prospective cohort study

Elliot B. Tapper, Michelle Lai – 23 December 2015 – Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and associated with decreased quality of life (QOL). The currently available treatment is weight loss through lifestyle modification. However, longitudinal QOL data are lacking on whether weight loss improves QOL. We prospectively enrolled 151 patients with NAFLD from 2009 to 2014.

Actin‐like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial‐mesenchymal transition

Shuai Xiao, Rui‐Min Chang, Ming‐Yang Yang, Xiong Lei, Xiao Liu, Wen‐Bin Gao, Jing‐Lei Xiao, Lian‐Yue Yang – 23 December 2015 – Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide because of metastasis. Epithelial‐mesenchymal transition (EMT) is widely considered to be crucial to the invasion‐metastasis cascade during cancer progression. Actin‐like 6A (ACTL6A) is initially verified important for cell proliferation, differentiation, and migration. In this study, we find that ACTL6A plays an essential role in metastasis and EMT of HCC.

Histidine‐rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease

Matthias Bartneck, Viktor Fech, Josef Ehling, Olivier Govaere, Klaudia Theresa Warzecha, Kanishka Hittatiya, Mihael Vucur, Jérémie Gautheron, Tom Luedde, Christian Trautwein, Twan Lammers, Tania Roskams, Willi Jahnen‐Dechent, Frank Tacke – 23 December 2015 – Pathogen‐ and injury‐related danger signals as well as cytokines released by immune cells influence the functional differentiation of macrophages in chronic inflammation.

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