The neuroimmune guidance cue netrin‐1 controls resolution programs and promotes liver regeneration

Martin Schlegel, David Köhler, Andreas Körner, Tiago Granja, Andreas Straub, Martin Giera, Valbona Mirakaj – 17 November 2015 – Hepatic ischemia/reperfusion (I/R) is a major adverse reaction to liver transplantation, hemorrhagic shock, or resection. Recently, the anti‐inflammatory properties of the axonal guidance cue netrin‐1 were reported. Here, we demonstrate that netrin‐1 also impacts the resolution of inflammation and promotes hepatic repair and regeneration during liver I/R injury.

Antiviral therapy in chronic hepatitis B viral infection during pregnancy: A systematic review and meta‐analysis

Robert S. Brown, Brian J. McMahon, Anna S.F. Lok, John B. Wong, Ahmed T. Ahmed, Mohamed A. Mouchli, Zhen Wang, Larry J. Prokop, Mohammad Hassan Murad, Khaled Mohammed – 13 November 2015 – Perinatal or mother‐to‐child transmission (MTCT) of hepatitis B virus (HBV) remains the major risk factor for chronic HBV infection worldwide. In addition to hepatitis B immune globulin and vaccination, oral antiviral therapies in highly viremic mothers can further decrease MTCT of HBV.

Prospective validation of ab initio liver transplantation in hepatocellular carcinoma upon detection of risk factors for recurrence after resection

Joana Ferrer‐Fàbrega, Alejandro Forner, Alexandre Liccioni, Rosa Miquel, Víctor Molina, Miquel Navasa, Constantino Fondevila, Juan Carlos García‐Valdecasas, Jordi Bruix, Josep Fuster – 13 November 2015 – A decade ago we proposed to enlist for transplantation those patients with resected hepatocellular carcinoma in whom pathology registered pejorative histological markers (microvascular invasion and/or satellites; ab initio indication) and not wait for the appearance of recurrence. This study evaluates the outcome of this approach.

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