The neuroimmune guidance cue netrin‐1 controls resolution programs and promotes liver regeneration
Martin Schlegel, David Köhler, Andreas Körner, Tiago Granja, Andreas Straub, Martin Giera, Valbona Mirakaj – 17 November 2015 – Hepatic ischemia/reperfusion (I/R) is a major adverse reaction to liver transplantation, hemorrhagic shock, or resection. Recently, the anti‐inflammatory properties of the axonal guidance cue netrin‐1 were reported. Here, we demonstrate that netrin‐1 also impacts the resolution of inflammation and promotes hepatic repair and regeneration during liver I/R injury.