Ex vivo evaluation of 4 different viscoelastic assays for detecting moderate to severe coagulopathy during liver transplantation

Ezeldeen Abuelkasem, Michael A. Mazzeffi, Shu Yang Lu, Raymond M. Planinsic, Tetsuro Sakai, Kenichi A. Tanaka – 26 November 2015 – Prolonged prothrombin time (PT) and its ratio are routinely used for the assessment of candidates for liver transplantation (LT), but intraoperative coagulation management of transfusion is hindered by its long turnaround time.

Outcomes of adult‐to‐adult living donor liver transplantation in 321 recipients

Hideaki Uchiyama, Ken Shirabe, Koichi Kimura, Tomoharu Yoshizumi, Toru Ikegami, Norifumi Harimoto, Yoshihiko Maehara – 26 November 2015 – We conducted a retrospective investigation in order to clarify whether selecting the type of liver graft had an impact on outcomes of adult‐to‐adult living donor liver transplantation (AALDLT). Data from the medical records of the donors and the recipients of 321 consecutive cases of AALDLT performed between April 2004 and March 2014 were retrospectively analyzed.

Pretransplant echocardiographic parameters as markers of posttransplant outcomes in liver transplant recipients

Daniel Bushyhead, James N. Kirkpatrick, David Goldberg – 26 November 2015 – Despite advances in liver transplantation and preoperative risk stratification, there remains significant posttransplant morbidity and mortality from cardiovascular and renal disease. There are limited and conflicting data on the role of pretransplant echocardiography to predict these outcomes. The purpose of our study was to determine if pretransplant echocardiographic parameters were associated with posttransplant survival and the development of incident cardiovascular events and chronic kidney disease (CKD).

Usefulness of liver stiffness measurement during acute cellular rejection in liver transplantation

Gonzalo Crespo, Graciela Castro‐Narro, Ignacio García‐Juárez, Carlos Benítez, Pablo Ruiz, Lydia Sastre, Jordi Colmenero, Rosa Miquel, Alberto Sánchez‐Fueyo, Xavier Forns, Miquel Navasa – 26 November 2015 – Liver stiffness measurement (LSM) is a useful method to estimate liver fibrosis and portal hypertension. The inflammatory process that takes place in post–liver transplant acute cellular rejection (ACR) may also increase liver stiffness.

Cholestasis‐induced adaptive remodeling of interlobular bile ducts

Nachiket Vartak, Amruta Damle‐Vartak, Beate Richter, Olaf Dirsch, Uta Dahmen, Seddik Hammad, Jan G. Hengstler – 26 November 2015 – Cholestasis is a common complication in liver diseases that triggers a proliferative response of the biliary tree. Bile duct ligation (BDL) is a frequently used model of cholestasis in rodents. To determine which changes occur in the three‐dimensional (3D) architecture of the interlobular bile duct during cholestasis, we used 3D confocal imaging, surface reconstructions, and automated image quantification covering a period up to 28 days after BDL.

The rs2294918 E434K variant modulates patatin‐like phospholipase domain‐containing 3 expression and liver damage

Benedetta Donati, Benedetta Maria Motta, Piero Pingitore, Marica Meroni, Alessandro Pietrelli, Anna Alisi, Salvatore Petta, Chao Xing, Paola Dongiovanni, Benedetta del Menico, Raffaela Rametta, Rosellina Margherita Mancina, Sara Badiali, Anna Ludovica Fracanzani, Antonio Craxì, Silvia Fargion, Valerio Nobili, Stefano Romeo, Luca Valenti – 25 November 2015 – The patatin‐like phosholipase domain‐containing 3 (PNPLA3) rs738409 polymorphism (I148M) is a major determinant of hepatic fat and predisposes to the full spectrum of liver damage in nonalcoholic fatty liver disease (NAFLD).

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