Sarcopenia is associated with significant liver fibrosis independently of obesity and insulin resistance in nonalcoholic fatty liver disease: Nationwide surveys (KNHANES 2008‐2011)

Yong‐ho Lee, Seung Up Kim, Kijun Song, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Byung‐Wan Lee, Eun Seok Kang, Bong‐Soo Cha, Kwang‐Hyub Han – 5 December 2015 – Sarcopenia is associated with nonalcoholic fatty liver disease (NAFLD). This study investigated whether sarcopenia is associated with significant liver fibrosis in subjects with NAFLD. Data from the Korean National Health and Nutrition Examination Surveys 2008‐2011 database were analyzed. NALFD was defined by NAFLD liver fat score, comprehensive NAFLD score, or hepatic steatosis index.

Retinoid regulation of antiviral innate immunity in hepatocytes

Noell E. Cho, Bo‐Ram Bang, Purnima Gurung, Meng Li, Dahn L. Clemens, T. Michael Underhill, Laura P. James, Jenifer R. Chase, Takeshi Saito – 5 December 2015 – Persistent infection of hepatitis C virus (HCV) is one of the leading causes of end‐stage liver disease (ESLD), such as decompensated cirrhosis and liver cancer. Of particular note, nearly half of HCV‐infected people in the United States are reported to be heavy drinkers. This particular group of patients is known to rapidly progress to the ESLD.

Mutant p53 in concert with an interleukin‐27 receptor alpha deficiency causes spontaneous liver inflammation, fibrosis, and steatosis in mice

Denada Dibra, Xueqing Xia, Abhisek Mitra, Jeffry J. Cutrera, Guillermina Lozano, Shulin Li – 5 December 2015 – The cellular and molecular etiology of unresolved chronic liver inflammation remains obscure. Whereas mutant p53 has gain‐of‐function properties in tumors, the role of this protein in liver inflammation is unknown.

Persistence of seropositivity among persons vaccinated for hepatitis A during infancy by maternal antibody status: 15‐year follow‐up

Philip R. Spradling, Lisa R. Bulkow, Susan E. Negus, Chriss Homan, Michael G. Bruce, Brian J. McMahon – 5 December 2015 – The effect of passively transferred maternal antibody to hepatitis A virus (anti‐HAV) on the duration of seropositivity after hepatitis A vaccination during infancy and early childhood is unclear.

Biliary complications after living donor hepatectomy: A first report from India

Viniyendra Pamecha, Kishore Gurumoorthy Subramanya Bharathy, Senthil Kumar, Shridhar Vasantrao Sasturkar, Piyush Kumar Sinha – 26 November 2015 – Biliary complications after donor hepatectomy can result in significant morbidity. We herein present our experience of donor hepatectomy, highlighting surgical techniques that prevent complications. Data were reviewed from a prospectively maintained database of all donors who underwent hepatectomy from April 2011 to April 2015. Standard operative technique as described was followed in all patients.

Ex vivo evaluation of 4 different viscoelastic assays for detecting moderate to severe coagulopathy during liver transplantation

Ezeldeen Abuelkasem, Michael A. Mazzeffi, Shu Yang Lu, Raymond M. Planinsic, Tetsuro Sakai, Kenichi A. Tanaka – 26 November 2015 – Prolonged prothrombin time (PT) and its ratio are routinely used for the assessment of candidates for liver transplantation (LT), but intraoperative coagulation management of transfusion is hindered by its long turnaround time.

Outcomes of adult‐to‐adult living donor liver transplantation in 321 recipients

Hideaki Uchiyama, Ken Shirabe, Koichi Kimura, Tomoharu Yoshizumi, Toru Ikegami, Norifumi Harimoto, Yoshihiko Maehara – 26 November 2015 – We conducted a retrospective investigation in order to clarify whether selecting the type of liver graft had an impact on outcomes of adult‐to‐adult living donor liver transplantation (AALDLT). Data from the medical records of the donors and the recipients of 321 consecutive cases of AALDLT performed between April 2004 and March 2014 were retrospectively analyzed.

Pretransplant echocardiographic parameters as markers of posttransplant outcomes in liver transplant recipients

Daniel Bushyhead, James N. Kirkpatrick, David Goldberg – 26 November 2015 – Despite advances in liver transplantation and preoperative risk stratification, there remains significant posttransplant morbidity and mortality from cardiovascular and renal disease. There are limited and conflicting data on the role of pretransplant echocardiography to predict these outcomes. The purpose of our study was to determine if pretransplant echocardiographic parameters were associated with posttransplant survival and the development of incident cardiovascular events and chronic kidney disease (CKD).

Usefulness of liver stiffness measurement during acute cellular rejection in liver transplantation

Gonzalo Crespo, Graciela Castro‐Narro, Ignacio García‐Juárez, Carlos Benítez, Pablo Ruiz, Lydia Sastre, Jordi Colmenero, Rosa Miquel, Alberto Sánchez‐Fueyo, Xavier Forns, Miquel Navasa – 26 November 2015 – Liver stiffness measurement (LSM) is a useful method to estimate liver fibrosis and portal hypertension. The inflammatory process that takes place in post–liver transplant acute cellular rejection (ACR) may also increase liver stiffness.

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