Pretransplant echocardiographic parameters as markers of posttransplant outcomes in liver transplant recipients

Daniel Bushyhead, James N. Kirkpatrick, David Goldberg – 26 November 2015 – Despite advances in liver transplantation and preoperative risk stratification, there remains significant posttransplant morbidity and mortality from cardiovascular and renal disease. There are limited and conflicting data on the role of pretransplant echocardiography to predict these outcomes. The purpose of our study was to determine if pretransplant echocardiographic parameters were associated with posttransplant survival and the development of incident cardiovascular events and chronic kidney disease (CKD).

Outcomes of adult‐to‐adult living donor liver transplantation in 321 recipients

Hideaki Uchiyama, Ken Shirabe, Koichi Kimura, Tomoharu Yoshizumi, Toru Ikegami, Norifumi Harimoto, Yoshihiko Maehara – 26 November 2015 – We conducted a retrospective investigation in order to clarify whether selecting the type of liver graft had an impact on outcomes of adult‐to‐adult living donor liver transplantation (AALDLT). Data from the medical records of the donors and the recipients of 321 consecutive cases of AALDLT performed between April 2004 and March 2014 were retrospectively analyzed.

Ex vivo evaluation of 4 different viscoelastic assays for detecting moderate to severe coagulopathy during liver transplantation

Ezeldeen Abuelkasem, Michael A. Mazzeffi, Shu Yang Lu, Raymond M. Planinsic, Tetsuro Sakai, Kenichi A. Tanaka – 26 November 2015 – Prolonged prothrombin time (PT) and its ratio are routinely used for the assessment of candidates for liver transplantation (LT), but intraoperative coagulation management of transfusion is hindered by its long turnaround time.

Biliary complications after living donor hepatectomy: A first report from India

Viniyendra Pamecha, Kishore Gurumoorthy Subramanya Bharathy, Senthil Kumar, Shridhar Vasantrao Sasturkar, Piyush Kumar Sinha – 26 November 2015 – Biliary complications after donor hepatectomy can result in significant morbidity. We herein present our experience of donor hepatectomy, highlighting surgical techniques that prevent complications. Data were reviewed from a prospectively maintained database of all donors who underwent hepatectomy from April 2011 to April 2015. Standard operative technique as described was followed in all patients.

Down‐regulation of the cyclin‐dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis

Hui Guo, Li Jing, Yangzi Cheng, Vassilis Atsaves, Yi Lv, Tao Wu, Rujuan Su, Yamin Zhang, Ronghua Zhang, Wenbin Liu, George Z. Rassidakis, Yongchang Wei, Kejun Nan, Francois X. Claret – 25 November 2015 – Down‐regulation of p57 (KIP2) cyclin‐dependent kinase inhibitors accelerates the growth and invasion of hepatocellular carcinoma (HCC), suggesting that p57 may play an important role in liver carcinogenesis. However, the mechanism or oncogenic signal leading to p57 down‐regulation in HCC remains to be determined.

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Annabel Blasi, Virginia Hernandez‐Gea, Juan Carlos Reverter, Juan Carlos Garcia‐Pagán – 25 November 2015

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