Cholestasis‐induced adaptive remodeling of interlobular bile ducts

Nachiket Vartak, Amruta Damle‐Vartak, Beate Richter, Olaf Dirsch, Uta Dahmen, Seddik Hammad, Jan G. Hengstler – 26 November 2015 – Cholestasis is a common complication in liver diseases that triggers a proliferative response of the biliary tree. Bile duct ligation (BDL) is a frequently used model of cholestasis in rodents. To determine which changes occur in the three‐dimensional (3D) architecture of the interlobular bile duct during cholestasis, we used 3D confocal imaging, surface reconstructions, and automated image quantification covering a period up to 28 days after BDL.

The rs2294918 E434K variant modulates patatin‐like phospholipase domain‐containing 3 expression and liver damage

Benedetta Donati, Benedetta Maria Motta, Piero Pingitore, Marica Meroni, Alessandro Pietrelli, Anna Alisi, Salvatore Petta, Chao Xing, Paola Dongiovanni, Benedetta del Menico, Raffaela Rametta, Rosellina Margherita Mancina, Sara Badiali, Anna Ludovica Fracanzani, Antonio Craxì, Silvia Fargion, Valerio Nobili, Stefano Romeo, Luca Valenti – 25 November 2015 – The patatin‐like phosholipase domain‐containing 3 (PNPLA3) rs738409 polymorphism (I148M) is a major determinant of hepatic fat and predisposes to the full spectrum of liver damage in nonalcoholic fatty liver disease (NAFLD).

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Annabel Blasi, Virginia Hernandez‐Gea, Juan Carlos Reverter, Juan Carlos Garcia‐Pagán – 25 November 2015

Down‐regulation of the cyclin‐dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis

Hui Guo, Li Jing, Yangzi Cheng, Vassilis Atsaves, Yi Lv, Tao Wu, Rujuan Su, Yamin Zhang, Ronghua Zhang, Wenbin Liu, George Z. Rassidakis, Yongchang Wei, Kejun Nan, Francois X. Claret – 25 November 2015 – Down‐regulation of p57 (KIP2) cyclin‐dependent kinase inhibitors accelerates the growth and invasion of hepatocellular carcinoma (HCC), suggesting that p57 may play an important role in liver carcinogenesis. However, the mechanism or oncogenic signal leading to p57 down‐regulation in HCC remains to be determined.

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