Yonglong Zhang, Yanfeng Liu, Jinlin Duan, Haibo Yan, Jun Zhang, Huilu Zhang, Qi Fan, Feifei Luo, Guoquan Yan, Ke Qiao, Jie Liu – 13 December 2015 – Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related death. However, the underlying mechanism during hepatocarcinogenesis remains unclarified. Stable isotope labeling by amino acids in cell culture (SILAC) is a powerful quantitative strategy for proteome‐wide discovery of novel biomarkers in cancers. Hippocalcin‐like 1 (HPCAL1) is a calcium sensor protein.

Philippe Gual, Catherine Postic – 13 December 2015

Andres F. Carrion, Saira A. Khaderi, Norman L. Sussman – 13 December 2015

James Lin, Horng‐Yih Ou, Lee‐Ming Chuang, Ken C. Chiu – 13 December 2015

Giulio Marchesini, Salvatore Petta, Riccardo Dalle Grave – 11 December 2015 – Fatty liver accumulation results from an imbalance between lipid deposition and removal, driven by the hepatic synthesis of triglycerides and de novo lipogenesis. The habitual diet plays a relevant role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), and both risky (e.g., fructose) and protective foods (Mediterranean diet) have been described, but the contribution of excess calories remains pivotal. Accordingly, weight loss is the most effective way to promote liver fat removal.

Giulio Marchesini, Salvatore Petta, Riccardo Dalle Grave – 11 December 2015 – Fatty liver accumulation results from an imbalance between lipid deposition and removal, driven by the hepatic synthesis of triglycerides and de novo lipogenesis. The habitual diet plays a relevant role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), and both risky (e.g., fructose) and protective foods (Mediterranean diet) have been described, but the contribution of excess calories remains pivotal. Accordingly, weight loss is the most effective way to promote liver fat removal.

Xi Lan, Jidong Yan, Juan Ren, Bo Zhong, Jing Li, Yue Li, Li Liu, Jing Yi, Qingzhu Sun, Xudong Yang, Jian Sun, Liesu Meng, Wenhua Zhu, Rikard Holmdahl, Dongmin Li, Shemin Lu – 11 December 2015 – Cholesterol metabolism disorder in hepatocytes predicts a higher risk of metabolic syndrome (MetS). Long noncoding RNAs (lncRNAs) have emerged as critical players in cellular cholesterol metabolism, but their functions are not systematically clarified.

Aynur Unalp‐Arida, Constance E. Ruhl – 10 December 2015 – Nonalcoholic fatty liver disease (NAFLD) contributes to premature death along with obesity, diabetes, and cardiovascular disease (CVD). We examined whether hepatic steatosis (HS) on ultrasound and liver enzyme activities were associated with increased liver disease mortality in the U.S. National Health and Nutrition Examination Survey (NHANES), 1988‐1994, with up to 23 years of linked‐mortality data.

Annie‐Carole Tosello‐Trampont, Peter Krueger, Sowmya Narayanan, Susan G. Landes, Norbert Leitinger, Young S. Hahn – 10 December 2015 – Nonalcoholic steatohepatitis (NASH) affects 3%‐5% of the U.S. population, having severe clinical complications to the development of fibrosis and end‐stage liver diseases, such as cirrhosis and hepatocellular carcinoma. A critical cause of NASH is chronic systemic inflammation promoted by innate immune cells, such as liver macrophages (Mϕ) and natural killer (NK) cells.

Maura Dandri, Jan‐Hendrik Bockmann – 10 December 2015