Liver transplantation for “very early” intrahepatic cholangiocarcinoma: International retrospective study supporting a prospective assessment

G. Sapisochin, M. Facciuto, L. Rubbia‐Brandt, J. Marti, N. Mehta, F.Y. Yao, E. Vibert, D. Cherqui, D.R. Grant, R. Hernandez‐Alejandro, C.H. Dale, A. Cucchetti, A. Pinna, S. Hwang, S.G. Lee, V.G. Agopian, R.W. Busuttil, S. Rizvi, J.K. Heimbach, M. Montenovo, J. Reyes, M. Cesaretti, O. Soubrane, T. Reichman, J. Seal, P.T.W. Kim, G. Klintmalm, C. Sposito, V. Mazzaferro, P. Dutkowski, P.A. Clavien, C. Toso, P. Majno, N. Kneteman, C. Saunders, J.

Liver transplantation for “very early” intrahepatic cholangiocarcinoma: International retrospective study supporting a prospective assessment

G. Sapisochin, M. Facciuto, L. Rubbia‐Brandt, J. Marti, N. Mehta, F.Y. Yao, E. Vibert, D. Cherqui, D.R. Grant, R. Hernandez‐Alejandro, C.H. Dale, A. Cucchetti, A. Pinna, S. Hwang, S.G. Lee, V.G. Agopian, R.W. Busuttil, S. Rizvi, J.K. Heimbach, M. Montenovo, J. Reyes, M. Cesaretti, O. Soubrane, T. Reichman, J. Seal, P.T.W. Kim, G. Klintmalm, C. Sposito, V. Mazzaferro, P. Dutkowski, P.A. Clavien, C. Toso, P. Majno, N. Kneteman, C. Saunders, J.

Extracellular vesicles carry microRNA‐195 to intrahepatic cholangiocarcinoma and improve survival in a rat model

Ling Li, Klaus Piontek, Masaharu Ishida, Michel Fausther, Jonathan A. Dranoff, Rongdang Fu, Esteban Mezey, Stephen J. Gould, Francis K. Fordjour, Stephen J. Meltzer, Alphonse E. Sirica, Florin M. Selaru – 30 July 2016 – The cancer microenvironment plays a central role in cancer development, growth, and homeostasis. This paradigm suggests that cancer fibroblasts support cancers, probably in response to stimuli received from the cancer cells.

Assessment of the clinical cardiac drug‐drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys

Christopher P. Regan, Pierre Morissette, Hillary K. Regan, Jeffery J. Travis, Pamela Gerenser, Jianzhong Wen, Kevin Fitzgerald, Shaun Gruver, Joseph J. DeGeorge, Frederick J. Sannajust – 30 July 2016 – In 2015, European and U.S. health agencies issued warning letters in response to 9 reported clinical cases of severe bradycardia/bradyarrhythmia in hepatitis C virus (HCV)‐infected patients treated with sofosbuvir (SOF) in combination with other direct acting antivirals (DAAs) and the antiarrhythmic drug, amiodarone (AMIO).

Proton pump inhibitors as a risk factor for hepatic encephalopathy and spontaneous bacterial peritonitis in patients with cirrhosis with ascites

Gitte Dam, Hendrik Vilstrup, Hugh Watson, Peter Jepsen – 30 July 2016 – Proton pump inhibitors (PPIs) may be a risk factor for hepatic encephalopathy (HE) in patients with cirrhosis, possibly through translocation of gut bacteria, which can also lead to spontaneous bacterial peritonitis (SBP). We examined the associations between PPIs and development of HE or SBP in patients with cirrhosis with ascites. We used data from three 1‐year trials of satavaptan for ascites control. We used Cox regression to compare HE and SBP rates between users and nonusers of PPIs.

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