Daclatasvir with sofosbuvir and ribavirin for hepatitis C virus infection with advanced cirrhosis or post‐liver transplantation recurrence

Fred Poordad, Eugene R. Schiff, John M. Vierling, Charles Landis, Robert J. Fontana, Rong Yang, Fiona McPhee, Eric A. Hughes, Stephanie Noviello, Eugene S. Swenson – 11 January 2016 – Chronic hepatitis C virus (HCV) infection with advanced cirrhosis or post‐liver transplantation recurrence represents a high unmet medical need with no approved therapies effective across all HCV genotypes.

CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors

Ming Liu, Leilei Chen, Ning‐Fang Ma, Raymond Kwok Kei Chow, Yan Li, Yangyang Song, Tim Hon Man Chan, Shuo Fang, Xiaodong Yang, Shaoyan Xi, Lingxi Jiang, Yun Li, Ting‐Ting Zeng, Yan Li, Yun‐Fei Yuan, Xin‐Yuan Guan – 11 January 2016 – High‐grade tumors with poor differentiation usually show phenotypic resemblance to their developmental ancestral cells. Cancer cells that gain lineage precursor cell properties usually hijack developmental signaling pathways to promote tumor malignant progression. However, the molecular mechanisms underlying this process remain unclear.

Glial cell line–derived neurotrophic factor–induced mice liver defatting: A novel strategy to enable transplantation of steatotic livers

Sahar Taba Taba Vakili, Roshni Kailar, Khalidur Rahman, Behtash Ghazi Nezami, Simon Musyoka Mwangi, Frank A. Anania, Shanthi Srinivasan – 30 December 2015 – Moderate macrovesicular steatosis (>30%), which is present in almost 50% of livers considered for transplantation, increases the risk of primary graft dysfunction. Our previously published data showed that glial cell line–derived neurotrophic factor (GDNF) is protective against high‐fat diet (HFD)–induced hepatic steatosis in mice.

Noncirrhotic complete obliterative portal vein thrombosis: Novel management using trans‐splenic transjugular intrahepatic portosystemic shunt with portal vein recanalization

Joseph Ralph Kallini, Ahmed Gabr, Laura Kulik, Daniel Ganger, Robert Lewandowski, Bartley Thornburg, Riad Salem – 28 December 2015

Noncirrhotic complete obliterative portal vein thrombosis: Novel management using trans‐splenic transjugular intrahepatic portosystemic shunt with portal vein recanalization

Joseph Ralph Kallini, Ahmed Gabr, Laura Kulik, Daniel Ganger, Robert Lewandowski, Bartley Thornburg, Riad Salem – 28 December 2015

Liver transplantation in the mouse: Insights into liver immunobiology, tissue injury, and allograft tolerance

Shinichiro Yokota, Osamu Yoshida, Yoshihiro Ono, David A. Geller, Angus W. Thomson – 28 December 2015 – The surgically demanding mouse orthotopic liver transplant model was first described in 1991. It has proved to be a powerful research tool for the investigation of liver biology, tissue injury, the regulation of alloimmunity and tolerance induction, and the pathogenesis of specific liver diseases.

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