A nationwide survey of hepatitis E viral infection in French blood donors

Jean Michel Mansuy, Pierre Gallian, Chloé Dimeglio, Karine Saune, Catherine Arnaud, Bertrand Pelletier, Pascal Morel, Dominique Legrand, Pierre Tiberghien, Jacques Izopet – 11 January 2016 – Most cases of hepatitis E viral (HEV) infection in developed countries are autochthonous. Nevertheless, the reported seroprevalence of HEV varies greatly depending on the geographical area and the performance of the immunoassay used.

A nationwide survey of hepatitis E viral infection in French blood donors

Jean Michel Mansuy, Pierre Gallian, Chloé Dimeglio, Karine Saune, Catherine Arnaud, Bertrand Pelletier, Pascal Morel, Dominique Legrand, Pierre Tiberghien, Jacques Izopet – 11 January 2016 – Most cases of hepatitis E viral (HEV) infection in developed countries are autochthonous. Nevertheless, the reported seroprevalence of HEV varies greatly depending on the geographical area and the performance of the immunoassay used.

miR‐28‐5p‐IL‐34‐macrophage feedback loop modulates hepatocellular carcinoma metastasis

Shao‐Lai Zhou, Zhi‐Qiang Hu, Zheng‐Jun Zhou, Zhi Dai, Zheng Wang, Ya Cao, Jia Fan, Xiao‐Wu Huang, Jian Zhou – 11 January 2016 – MicroRNAs (miRNAs) play a critical role in regulation of tumor metastasis. However, the role of these molecules in hepatocellular carcinoma (HCC) has not been fully elucidated. In this study, we employed miRNA‐sequencing and identified 22 miRNAs involved in HCC metastasis. One of these, miR‐28‐5p, was down‐regulated in HCCs. This down‐regulation correlated with tumor metastasis, recurrence, and poor survival.

Canonical NF‐κB signaling in hepatocytes acts as a tumor‐suppressor in hepatitis B virus surface antigen‐driven hepatocellular carcinoma by controlling the unfolded protein response

Yoshiaki Sunami, Marc Ringelhan, Enikö Kokai, Miao Lu, Tracy O'Connor, Anna Lorentzen, Achim Weber, Ann‐Katrin Rodewald, Beat Müllhaupt, Luigi Terracciano, Sarah Gul, Sebastian Wissel, Frank Leithäuser, Daniel Krappmann, Petra Riedl, Daniel Hartmann, Reinhold Schirmbeck, Pavel Strnad, Norbert Hüser, Jörg Kleeff, Helmut Friess, Roland M Schmid, Fabian Geisler, Thomas Wirth, Mathias Heikenwalder – 11 January 2016 – Chronic hepatitis B virus (HBV) infection remains the most common risk factor for hepatocellular carcinoma (HCC).

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