Herbert Tilg, Alexander R. Moschen, Gyongyi Szabo – 16 January 2016 – Both alcoholic liver disease (ALD) and nonalcoholic fatty liver disease are characterized by massive lipid accumulation in the liver accompanied by inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma in a substantial subgroup of patients. At several stages in these diseases, mediators of the immune system, such as cytokines or inflammasomes, are crucially involved.

Herbert Tilg, Alexander R. Moschen, Gyongyi Szabo – 16 January 2016 – Both alcoholic liver disease (ALD) and nonalcoholic fatty liver disease are characterized by massive lipid accumulation in the liver accompanied by inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma in a substantial subgroup of patients. At several stages in these diseases, mediators of the immune system, such as cytokines or inflammasomes, are crucially involved.

Anna S. Lok – 16 January 2016

Zhi‐Feng Zhang, Zhi‐Jun Duan – 16 January 2016

Satoru Todo, Kenichiro Yamashita, Ryoichi Goto, Masaaki Zaitsu, Akihisa Nagatsu, Tetsu Oura, Masaaki Watanabe, Takeshi Aoyagi, Tomomi Suzuki, Tsuyoshi Shimamura, Toshiya Kamiyama, Norihiro Sato, Junichi Sugita, Kanako Hatanaka, Hisashi Bashuda, Sonoko Habu, Anthony J. Demetris, Ko Okumura – 16 January 2016 – Potent immunosuppressive drugs have significantly improved early patient survival after liver transplantation (LT). However, long‐term results remain unsatisfactory because of adverse events that are largely associated with lifelong immunosuppression.

Hamish Innes, Sharon J. Hutchinson, Niels Obel, Peer B. Christensen, Esther J. Aspinall, David Goldberg, Henrik Krarup, Scott A. McDonald, Allan McLeod, Amanda Weir, Lars H. Omland – 16 January 2016 – Liver mortality among individuals with chronic hepatitis C (CHC) infection is common, but the relative contribution of CHC per se versus adverse health behaviors is uncertain. We explored data on spontaneous resolvers of hepatitis C virus (HCV) as a benchmark group to uncover the independent contribution of CHC on liver mortality.

Tamar H. Taddei – 13 January 2016

Riccardo Lencioni, Thierry de Baere, Michael C. Soulen, William S. Rilling, Jean‐Francois H. Geschwind – 13 January 2016 – Transarterial chemoembolization (TACE) using lipiodol‐based regimens, including the administration of an anticancer‐in‐oil emulsion followed by embolic agents, is widely used in the treatment of hepatocellular carcinoma (HCC). This approach has been supported by meta‐analyses of randomized, controlled trials (RCTs) performed more than a decade ago. We performed a systematic review to understand current efficacy and safety data of lipiodol TACE in treatment of HCC.

Seema S. Desai, Jason C. Tung, Vivian X. Zhou, James P. Grenert, Yann Malato, Milad Rezvani, Regina Español‐Suñer, Holger Willenbring, Valerie M. Weaver, Tammy T. Chang – 11 January 2016 – Matrix rigidity has important effects on cell behavior and is increased during liver fibrosis; however, its effect on primary hepatocyte function is unknown. We hypothesized that increased matrix rigidity in fibrotic livers would activate mechanotransduction in hepatocytes and lead to inhibition of liver‐specific functions.

Marco Fiore, Lorenzo Andreana, Sebastiano Leone – 11 January 2016