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Christine E. McLaren, James C. Barton, V. Nathan Subramaniam, Grant A. Ramm, Pradyumna D. Phatak, Mary J. Emond, Lyle C. Gurrin, Paul C. Adams, Lawrie W. Powell, Gregory J. Anderson, Gordon D. McLaren – 4 February 2016

Protein tyrosine phosphatase 1B dephosphorylates PITX1 and regulates p120RasGAP in hepatocellular carcinoma

Wei‐Tien Tai, Yao‐Li Chen, Pei‐Yi Chu, Li‐Ju Chen, Man‐Hsin Hung, Chung‐Wai Shiau, Jui‐Wen Huang, Ming‐Hsien Tsai, Kuen‐Feng Chen – 3 February 2016 – The effective therapeutic targets for hepatocellular carcinoma remain limited. Pituitary homeobox 1 (PITX1) functions as a tumor suppressor in hepatocarcinogenesis by regulating the expression level of Ras guanosine triphosphatase‐activating protein. Here, we report that protein tyrosine phosphatases 1B (PTP1B) directly dephosphorylated PITX1 at Y160, Y175, and Y179 to further weaken the protein stability of PITX.

A low‐cost, user‐friendly electroencephalographic recording system for the assessment of hepatic encephalopathy

Sami Schiff, Mariella Casa, Valeria Di Caro, Daniele Aprile, Giuseppe Spinelli, Michele De Rui, Paolo Angeli, Piero Amodio, Sara Montagnese – 2 February 2016 – Electroencephalography (EEG) is useful to objectively diagnose/grade hepatic encephalopathy (HE) across its spectrum of severity. However, it requires expensive equipment, and hepatogastroenterologists are generally unfamiliar with its acquisition/interpretation.

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