Effect of diabetes and acute rejection on liver transplant outcomes: An analysis of the organ procurement and transplantation network/united network for organ sharing database

Hung‐Tien Kuo, Erik Lum, Paul Martin, Suphamai Bunnapradist – 6 February 2016 – The effects of diabetic status and acute rejection (AR) on liver transplant outcomes are largely unknown. We studied 13,736 liver recipients from the United Network for Organ Sharing/Organ Procurement Transplant Network database who underwent transplantation between 2004 and 2007 with a functioning graft for greater than 1 year.

Relevance of activated hepatic stellate cells in predicting the development of pediatric liver allograft fibrosis

Carla Venturi, Raymond Reding, Jorge Abarca Quinones, Etienne Sokal, Jacques Rahier, Javier Bueno, Christine Sempoux – 6 February 2016 – Activated hepatic stellate cells (HSCs) are the main collagen‐producing cells in liver fibrogenesis. With the purpose of analyzing their presence and relevance in predicting liver allograft fibrosis development, 162 liver biopsies of 54 pediatric liver transplantation (LT) recipients were assessed at 6 months, 3 years, and 7 years after LT.

Impaired physical function following pediatric LT

Amy G. Feldman, Katie Neighbors, Shubhra Mukherjee, Melanie Rak, James W. Varni, Estella M. Alonso – 6 February 2016 – The purpose of this article is to investigate the spectrum of physical function of pediatric liver transplantation (LT) recipients 12‐24 months after LT. Review data were collected through the functional outcomes group, an ancillary study of the Studies of Pediatric Liver Transplantation registry. Patients were eligible if they had survived LT by 12‐24 months.

Atrioventricular conduction disturbances immediately after hepatic graft reperfusion and their outcomes in patients undergoing liver transplantation

Sung‐Hoon Kim, Young‐Jin Moon, Sooho Lee, Sung‐Moon Jeong, Jun‐Gol Song, Gyu‐Sam Hwang – 6 February 2016 – Hemodynamic perturbation during hepatic graft reperfusion in patients undergoing liver transplantation (LT) is challenging and is frequently accompanied by bradyarrhythmia and even asystole. However, detailed data on electrocardiographic (ECG) changes during reperfusion are almost nonexistent, although the correct diagnosis by record is important for the treatment. We aimed to identify ECG rhythm disturbances during graft reperfusion and to investigate risk factors and outcomes.

Development and validation of a noninvasive prediction model for nonalcoholic steatohepatitis resolution after lifestyle intervention

Eduardo Vilar‐Gomez, Ali Yasells‐Garcia, Yadina Martinez‐Perez, Luis Calzadilla‐Bertot, Ana Torres‐Gonzalez, Bienvenido Gra‐Oramas, Licet Gonzalez‐Fabian, Oscar Villa‐Jimenez, Scott L. Friedman, Moises Diago, Manuel Romero‐Gomez – 5 February 2016 – Liver biopsy is the gold standard method to assess nonalcoholic steatohepatitis (NASH) resolution after therapeutic interventions. We developed and validated a simple and noninvasive scoring system to predict NASH resolution without fibrosis worsening after 1 year of lifestyle intervention.

Cancer Stem cells and their cellular origins in primary liver and biliary tract cancers

Tsunekazu Oikawa – 5 February 2016 – Liver and biliary tract cancers are highly aggressive, are heterogeneous in their phenotypic traits, and result in clinical outcomes that are difficult to manage. Cancers have subpopulations of cells termed “cancer stem cells” (CSCs) that share common intrinsic signaling pathways for self‐renewal and differentiation with normal stem cells. These CSCs likely have the potential to evolve over time and to give rise to new genetically and functionally diverse subclones by accumulating genetic mutations.

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