Matthias S. Matter, Jens U. Marquardt, Jesper B. Andersen, Cristina Quintavalle, Nikolay Korokhov, Jim K. Stauffer, Kosuke Kaji, Thomas Decaens, Luca Quagliata, Fathi Elloumi, Tanya Hoang, Alfredo Molinolo, Elizabeth A. Conner, Achim Weber, Mathias Heikenwalder, Valentina M. Factor, Snorri S. Thorgeirsson – 4 February 2016 – The majority of hepatocellular carcinoma develops in the background of chronic liver inflammation caused by viral hepatitis and alcoholic or nonalcoholic steatohepatitis.

Sanda Win, Tin Aung Than, Robert Win Maw Min, Mariam Aghajan, Neil Kaplowitz – 4 February 2016 – Sustained c‐Jun N‐terminal kinase (JNK) activation has been implicated in many models of cell death and tissue injury. Phosphorylated JNK (p‐JNK) interacts with the mitochondrial outer membrane SH3 homology associated BTK binding protein (Sab, or SH3BP5). Using knockdown or liver‐specific deletion of Sab, we aimed to elucidate the consequences of this interaction on mitochondrial function in isolated mitochondria and liver injury models in vivo.

Joel T. Adler, Joseph A. Hyder, James F. Markmann, David A. Axelrod, Heidi Yeh – 4 February 2016

Shu‐Chen Hsiao, Chien‐Te Lee, Sung‐Nan Pei – 4 February 2016

Wei‐Tien Tai, Yao‐Li Chen, Pei‐Yi Chu, Li‐Ju Chen, Man‐Hsin Hung, Chung‐Wai Shiau, Jui‐Wen Huang, Ming‐Hsien Tsai, Kuen‐Feng Chen – 3 February 2016 – The effective therapeutic targets for hepatocellular carcinoma remain limited. Pituitary homeobox 1 (PITX1) functions as a tumor suppressor in hepatocarcinogenesis by regulating the expression level of Ras guanosine triphosphatase‐activating protein. Here, we report that protein tyrosine phosphatases 1B (PTP1B) directly dephosphorylated PITX1 at Y160, Y175, and Y179 to further weaken the protein stability of PITX.

Sami Schiff, Mariella Casa, Valeria Di Caro, Daniele Aprile, Giuseppe Spinelli, Michele De Rui, Paolo Angeli, Piero Amodio, Sara Montagnese – 2 February 2016 – Electroencephalography (EEG) is useful to objectively diagnose/grade hepatic encephalopathy (HE) across its spectrum of severity. However, it requires expensive equipment, and hepatogastroenterologists are generally unfamiliar with its acquisition/interpretation.

Michael G. Ison – 2 February 2016

David Hervás, Agustín Lahoz – 29 January 2016

Christopher Moore – 29 January 2016

Miguel A. Lalama, Yasser Saloum – 29 January 2016