A new HIF‐1α/RANTES‐driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice
Mei Yee Koh, Mihai Gagea, Timothy Sargis, Robert Lemos, Geoffrey Grandjean, Adriana Charbono, Vasileos Bekiaris, John Sedy, Galina Kiriakova, Xiuping Liu, Lewis R. Roberts, Carl Ware, Garth Powis – 22 January 2016 – The hypoxia‐inducible factor (HIF), HIF‐1, is a central regulator of the response to low oxygen or inflammatory stress and plays an essential role in survival and function of immune cells. However, the mechanisms regulating nonhypoxic induction of HIF‐1 remain unclear.