Novel approach for heart failure treatment after liver transplantation
Marina Moguilevitch, Michael Rufino, Jonathan Leff, Ellise Delphin – 9 June 2015
Propensity score‐based survival benefit of simultaneous liver‐kidney transplant over liver transplant alone for recipients with pretransplant renal dysfunction
Pratima Sharma, Xu Shu, Douglas E. Schaubel, Randall S. Sung, John C. Magee – 9 June 2015 – The survival benefit of simultaneous liver‐kidney transplantation (SLKT) over liver transplantation alone (LTA) is unclear from the current literature. Additionally, the role of donor kidney quality, measured by the kidney donor risk index (KDRI), in survival benefit of SLKT is not studied.
The new hepatitis C virus bottleneck: Can delaying therapy be justified?
Tracey G. Simon, Raymond T. Chung – 8 June 2015
Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma
Yinying Lu, Wanping Xu, Junfang Ji, Dechun Feng, Carole Sourbier, Youfeng Yang, Jianhui Qu, Zhen Zeng, Chunping Wang, Xiujuan Chang, Yan Chen, Alok Mishra, Max Xu, Min‐Jung Lee, Sunmin Lee, Jane Trepel, W. Marston Linehan, Xinwei Wang, Yongping Yang, Len Neckers – 8 June 2015 – The cell fate determinant Numb is aberrantly expressed in cancer. Numb is alternatively spliced, with one isoform containing a long proline‐rich region (PRRL) compared to the other with a short PRR (PRRS). Recently, PRRL was reported to enhance proliferation of breast and lung cancer cells.
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Mingjiang Xu, Dechun Feng, Bin Gao – 5 June 2015
MiR‐199a‐5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer
Weijie Guo, Zhaoping Qiu, Zhichao Wang, Qifeng Wang, Ning Tan, Taoyang Chen, Zhiao Chen, Shenglin Huang, Jianren Gu, Jinjun Li, Ming Yao, Yingjun Zhao, Xianghuo He – 5 June 2015 – Cancer cells possess a unique metabolic phenotype that allows them to preferentially utilize glucose through aerobic glycolysis. This phenomenon is referred to as the “Warburg effect.” Accumulating evidence suggests that microRNAs (miRNAs), a class of small noncoding regulatory RNAs, interact with oncogenes/tumor suppressors and induce such metabolic reprograming in cancer cells.
Lipocalin‐2 (NGAL/LCN2), a “help‐me” signal in organ inflammation
Anastasia Asimakopoulou, Erawan Borkham‐Kamphorst, Frank Tacke, Ralf Weiskirchen – 5 June 2015
A novel, minimally invasive technique for management of peristomal varices
James H. Tabibian, Barham K. Abu Dayyeh, Gregory J. Gores, Michael J. Levy – 4 June 2015
Impact of multiple transarterial chemoembolization treatments on hepatocellular carcinoma for patients awaiting liver transplantation
Quirino Lai, Jan Lerut, For the European Hepatocellular Cancer Liver Transplant (EurHeCaLT) Study Group – 4 June 2015
Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis
James H. Tabibian, Steven P. O'Hara, Christy E. Trussoni, Pamela S. Tietz, Patrick L. Splinter, Taofic Mounajjed, Lee R. Hagey, Nicholas F. LaRusso – 4 June 2015 – Primary sclerosing cholangitis (PSC) is a chronic, idiopathic, fibroinflammatory cholangiopathy. The role of the microbiota in PSC etiopathogenesis may be fundamentally important, yet remains obscure. We tested the hypothesis that germ‐free (GF) mutltidrug resistance 2 knockout (mdr2−/−) mice develop a distinct PSC phenotype, compared to conventionally housed (CV) mdr2−/− mice.