Hepatic encephalopathy: New treatments
Anna Hadjihambi, Rajiv Jalan – 27 May 2015 – Watch a video presentation of this article
Noncirrhotic portal hypertension in the pediatric population
Amy G. Feldman, Ronald J. Sokol, – 27 May 2015 – Watch a video presentation of this article
Noncirrhotic portal hypertension: Pathology and nomenclature
David E. Kleiner – 27 May 2015 – Watch a video presentation of this article
Noncirrhotic portal hypertension: Pathology and nomenclature
David E. Kleiner – 27 May 2015 – Watch a video presentation of this article
Outcomes of pregnancy following liver transplantation: The King's College Hospital experience
Rachel H. Westbrook, Andrew D. Yeoman, Kosh Agarwal, Varuna Aluvihare, John O'Grady, Nigel Heaton, Leonie Penna, Michael A. Heneghan – 26 May 2015 – Reports of pregnancy in liver transplantation (LT) patients have largely favorable outcomes. Concerns remain with regards to maternal and graft risk, optimal immunosuppression (IS), and fetal outcomes. We review all post‐LT pregnancies at our center with regard to the outcomes and safety for the patient, graft, and fetus. A total of 117 conceptions occurred in 79 patients. Median age at conception was 29 years.
Patients with chronic hepatitis B should be screened for hepatocellular carcinoma regardless of liver stiffness measurement
Philippe Sultanik, Philippe Sogni, Jean‐François Meritet, Stanislas Pol, Vincent Mallet – 23 May 2015
Acute hepatitis C virus infection induces anti‐host cell receptor antibodies with virus‐neutralizing properties
Rajiv G. Tawar, Che C. Colpitts, Jörg Timm, Tanja Fehm, Michael Roggendorf, Helga Meisel, Nicolas Meyer, François Habersetzer, François‐Loïc Cosset, Thomas Berg, Mirjam B. Zeisel, Thomas F. Baumert – 23 May 2015 – Hepatitis C virus (HCV) causes persistent infection in the majority of infected individuals. The mechanisms of persistence and clearance are only partially understood. Antibodies (Abs) against host cell entry receptors have been shown to inhibit HCV infection in cell culture and animal models.
Rejection triggers liver transplant tolerance: Involvement of mesenchyme‐mediated immune control mechanisms in mice
Miwa Morita, Daniel Joyce, Charles Miller, John J. Fung, Lina Lu, Shiguang Qian – 22 May 2015 – Liver tolerance was initially recognized by the spontaneous acceptance of liver allografts in many species. The underlying mechanisms are not completely understood. However, liver transplant (LT) tolerance absolutely requires interferon (IFN)‐γ, a rejection‐associated inflammatory cytokine.
Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor–induced epithelial‐mesenchymal transition
Zhi‐Chao Wang, Qiang Gao, Jie‐Yi Shi, Wei‐Jie Guo, Liu‐Xiao Yang, Xin‐Yang Liu, Long‐Zi Liu, Li‐Jie Ma, Meng Duan, Ying‐Jun Zhao, Yong‐Na Wu, Dong‐Mei Gao, Xiao‐Ying Wang, Guo‐Ming Shi, Zhen‐Bin Ding, Ai‐Wu Ke, Qi‐Qun Tang, Ya Cao, Jian Zhou, Jia Fan – 22 May 2015 – Hepatocellular carcinoma (HCC) is the third‐most lethal cancer worldwide. Understanding the molecular pathogenesis of HCC recurrence and metastasis is the key to improve patients’ prognosis.