Liver transplantation for critically Ill patients with secondary sclerosing cholangitis: Outcome and complications

Torsten Voigtländer, Elmar Jaeckel, Frank Lehner, Michael P. Manns, Tim O. Lankisch – 9 June 2015 – Secondary sclerosing cholangitis in critically ill patients (SSC‐CIP) is a destructive cholangiopathy with a poor prognosis. Liver transplantation (LT) is an established therapeutic option in end‐stage liver disease but is insufficiently evaluated in patients with SSC‐CIP. Our aim was the retrospective analysis of the outcome and complications of patients with SSC‐CIP undergoing LT between 2002 and 2012.

Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma

Yinying Lu, Wanping Xu, Junfang Ji, Dechun Feng, Carole Sourbier, Youfeng Yang, Jianhui Qu, Zhen Zeng, Chunping Wang, Xiujuan Chang, Yan Chen, Alok Mishra, Max Xu, Min‐Jung Lee, Sunmin Lee, Jane Trepel, W. Marston Linehan, Xinwei Wang, Yongping Yang, Len Neckers – 8 June 2015 – The cell fate determinant Numb is aberrantly expressed in cancer. Numb is alternatively spliced, with one isoform containing a long proline‐rich region (PRRL) compared to the other with a short PRR (PRRS). Recently, PRRL was reported to enhance proliferation of breast and lung cancer cells.

MiR‐199a‐5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer

Weijie Guo, Zhaoping Qiu, Zhichao Wang, Qifeng Wang, Ning Tan, Taoyang Chen, Zhiao Chen, Shenglin Huang, Jianren Gu, Jinjun Li, Ming Yao, Yingjun Zhao, Xianghuo He – 5 June 2015 – Cancer cells possess a unique metabolic phenotype that allows them to preferentially utilize glucose through aerobic glycolysis. This phenomenon is referred to as the “Warburg effect.” Accumulating evidence suggests that microRNAs (miRNAs), a class of small noncoding regulatory RNAs, interact with oncogenes/tumor suppressors and induce such metabolic reprograming in cancer cells.

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