Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury

Seung‐Hyun Kim, Katy Saide, John Farrell, Lee Faulkner, Arun Tailor, Monday Ogese, Ann K. Daly, Munir Pirmohamed, B. Kevin Park, Dean J. Naisbitt – 22 May 2015 – Drug‐induced liver injury (DILI) frequently has a delayed onset with several human leukocyte antigen (HLA) genotypes affecting susceptibility, indicating a potential role for the adaptive immune system in the disease. The aim of this study was to investigate whether drug‐responsive T lymphocytes are detectable in patients who developed DILI with the combination, antimicrobial amoxicillin‐clavulanate.

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

Young Suk Jo, Dongryeol Ryu, Adriano Maida, Xu Wang, Ronald M. Evans, Kristina Schoonjans, Johan Auwerx – 22 May 2015 – Nuclear receptor corepressor 1 (NCoR1) is a transcriptional coregulator that has wide‐ranging effects on gene expression patterns. In the liver, NCoR1 represses lipid synthesis in the fasting state, whereas it inhibits activation of peroxisome proliferator‐activated receptor alpha (PPARα) upon feeding, thereby blunting ketogenesis.

Temoporfin improves efficacy of photodynamic therapy in advanced biliary tract carcinoma: A multicenter prospective phase II study

Andrej Wagner, Ulrike W. Denzer, Daniel Neureiter, Tobias Kiesslich, Andreas Puespoeck, Erik A.J. Rauws, Klaus Emmanuel, Nora Degenhardt, Ulrich Frick, Ulrich Beuers, Ansgar W. Lohse, Frieder Berr, Gernot W. Wolkersdörfer – 20 May 2015 – Photodynamic therapy using porfimer (P‐PDT) improves palliation and survival in nonresectable hilar bile duct cancer. Tumoricidal penetration depth of temoporfin‐PDT (T‐PDT) is twice that of P‐PDT. In a single‐arm phase II study we investigated the safety, efficacy, survival time, and adverse events of T‐PDT compared with previous data on P‐PDT.

A multicenter study of 30 days complications after deceased donor liver transplantation in the model for end‐stage liver disease score era

Anup Parikh, Kenneth W. Washburn, Lea Matsuoka, Urvashi Pandit, Jennifer E. Kim, Jose Almeda, Cesar Mora‐Esteves, Glenn Halff, Yuri Genyk, Bart Holland, Dorian J. Wilson, Linda Sher, Baburao Koneru – 19 May 2015 – Knowledge of risk factors for posttransplant complications is likely to improve patient outcomes. Few large studies of all early postoperative complications after deceased donor liver transplantation (DDLT) exist. Therefore, we conducted a retrospective, cohort study of 30‐day complications, their risk factors, and the impact on outcomes after DDLT.

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Susan Holtzman, Hance A. Clarke, Stuart A. McCluskey, Kara Turcotte, David Grant, Joel Katz – 19 May 2015

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