Yasuhiro Yamazaki, Kenta Yasui, Takahiro Hashizume, Arisa Suto, Ayaka Mori, Yuzuki Murata, Masahiko Yamaguchi, Akira Ikari, Junko Sugatani – 22 May 2015 – The adenosine triphosphate–binding cassette (ABC) half‐transporters Abcg5 and Abcg8 promote the secretion of neutral sterol into bile. Studies have demonstrated the diet‐induced gene expression of these transporters, but the regulation of their trafficking when the nutritional status changes in the liver remains to be elucidated.

Anggakusuma, Inés Romero‐Brey, Carola Berger, Che C. Colpitts, Tujana Boldanova, Michael Engelmann, Daniel Todt, Paula Monteiro Perin, Patrick Behrendt, Florian W.R. Vondran, Shuting Xu, Christine Goffinet, Luis M. Schang, Markus H. Heim, Ralf Bartenschlager, Thomas Pietschmann, Eike Steinmann – 22 May 2015 – Hepatitis C virus (HCV) is a positive‐strand RNA virus that primarily infects human hepatocytes. Infections with HCV constitute a global health problem, with 180 million people currently chronically infected.

Anggakusuma, Inés Romero‐Brey, Carola Berger, Che C. Colpitts, Tujana Boldanova, Michael Engelmann, Daniel Todt, Paula Monteiro Perin, Patrick Behrendt, Florian W.R. Vondran, Shuting Xu, Christine Goffinet, Luis M. Schang, Markus H. Heim, Ralf Bartenschlager, Thomas Pietschmann, Eike Steinmann – 22 May 2015 – Hepatitis C virus (HCV) is a positive‐strand RNA virus that primarily infects human hepatocytes. Infections with HCV constitute a global health problem, with 180 million people currently chronically infected.

Vishal C. Patel, Debbie L. Shawcross – 22 May 2015

Adeel R. Seyal, Fernanda D. Gonzalez‐Guindalini, Atilla Arslanoglu, Carla B. Harmath, Robert J. Lewandowski, Riad Salem, Vahid Yaghmai – 22 May 2015 – The purpose of our study was to evaluate the reproducibility of Modified Response Evaluation Criteria in Solid Tumors (mRECIST) in hepatocellular carcinoma (HCC) lesions undergoing transarterial radioembolization (TARE) therapy and to determine whether mRECIST reproducibility is affected by the enhancement pattern of HCC. One hundred and three HCC lesions from 103 patients treated with TARE were evaluated.

Iina Tuominen, Simon W. Beaven – 22 May 2015

Seung‐Hyun Kim, Katy Saide, John Farrell, Lee Faulkner, Arun Tailor, Monday Ogese, Ann K. Daly, Munir Pirmohamed, B. Kevin Park, Dean J. Naisbitt – 22 May 2015 – Drug‐induced liver injury (DILI) frequently has a delayed onset with several human leukocyte antigen (HLA) genotypes affecting susceptibility, indicating a potential role for the adaptive immune system in the disease. The aim of this study was to investigate whether drug‐responsive T lymphocytes are detectable in patients who developed DILI with the combination, antimicrobial amoxicillin‐clavulanate.

Shu‐hao Hsu, Andrew W. Duncan – 22 May 2015

Young Suk Jo, Dongryeol Ryu, Adriano Maida, Xu Wang, Ronald M. Evans, Kristina Schoonjans, Johan Auwerx – 22 May 2015 – Nuclear receptor corepressor 1 (NCoR1) is a transcriptional coregulator that has wide‐ranging effects on gene expression patterns. In the liver, NCoR1 represses lipid synthesis in the fasting state, whereas it inhibits activation of peroxisome proliferator‐activated receptor alpha (PPARα) upon feeding, thereby blunting ketogenesis.

Andrej Wagner, Ulrike W. Denzer, Daniel Neureiter, Tobias Kiesslich, Andreas Puespoeck, Erik A.J. Rauws, Klaus Emmanuel, Nora Degenhardt, Ulrich Frick, Ulrich Beuers, Ansgar W. Lohse, Frieder Berr, Gernot W. Wolkersdörfer – 20 May 2015 – Photodynamic therapy using porfimer (P‐PDT) improves palliation and survival in nonresectable hilar bile duct cancer. Tumoricidal penetration depth of temoporfin‐PDT (T‐PDT) is twice that of P‐PDT. In a single‐arm phase II study we investigated the safety, efficacy, survival time, and adverse events of T‐PDT compared with previous data on P‐PDT.