Hepatic encephalopathy: New treatments
Anna Hadjihambi, Rajiv Jalan – 27 May 2015 – Watch a video presentation of this article
Surgical management of noncirrhotic portal hypertension
Josep Marti, Ganesh Gunasekaran, Kishore Iyer, Myron Schwartz – 27 May 2015 – Watch a video presentation of this article
Idiopathic noncirrhotic portal hypertension: What is it?
Guadalupe Garcia‐Tsao – 27 May 2015 – Watch a video presentation of this article
Outcomes of pregnancy following liver transplantation: The King's College Hospital experience
Rachel H. Westbrook, Andrew D. Yeoman, Kosh Agarwal, Varuna Aluvihare, John O'Grady, Nigel Heaton, Leonie Penna, Michael A. Heneghan – 26 May 2015 – Reports of pregnancy in liver transplantation (LT) patients have largely favorable outcomes. Concerns remain with regards to maternal and graft risk, optimal immunosuppression (IS), and fetal outcomes. We review all post‐LT pregnancies at our center with regard to the outcomes and safety for the patient, graft, and fetus. A total of 117 conceptions occurred in 79 patients. Median age at conception was 29 years.
Acute hepatitis C virus infection induces anti‐host cell receptor antibodies with virus‐neutralizing properties
Rajiv G. Tawar, Che C. Colpitts, Jörg Timm, Tanja Fehm, Michael Roggendorf, Helga Meisel, Nicolas Meyer, François Habersetzer, François‐Loïc Cosset, Thomas Berg, Mirjam B. Zeisel, Thomas F. Baumert – 23 May 2015 – Hepatitis C virus (HCV) causes persistent infection in the majority of infected individuals. The mechanisms of persistence and clearance are only partially understood. Antibodies (Abs) against host cell entry receptors have been shown to inhibit HCV infection in cell culture and animal models.
Patients with chronic hepatitis B should be screened for hepatocellular carcinoma regardless of liver stiffness measurement
Philippe Sultanik, Philippe Sogni, Jean‐François Meritet, Stanislas Pol, Vincent Mallet – 23 May 2015
Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice
Young Suk Jo, Dongryeol Ryu, Adriano Maida, Xu Wang, Ronald M. Evans, Kristina Schoonjans, Johan Auwerx – 22 May 2015 – Nuclear receptor corepressor 1 (NCoR1) is a transcriptional coregulator that has wide‐ranging effects on gene expression patterns. In the liver, NCoR1 represses lipid synthesis in the fasting state, whereas it inhibits activation of peroxisome proliferator‐activated receptor alpha (PPARα) upon feeding, thereby blunting ketogenesis.
Pathological polyploidy in liver disease
Shu‐hao Hsu, Andrew W. Duncan – 22 May 2015
Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury
Seung‐Hyun Kim, Katy Saide, John Farrell, Lee Faulkner, Arun Tailor, Monday Ogese, Ann K. Daly, Munir Pirmohamed, B. Kevin Park, Dean J. Naisbitt – 22 May 2015 – Drug‐induced liver injury (DILI) frequently has a delayed onset with several human leukocyte antigen (HLA) genotypes affecting susceptibility, indicating a potential role for the adaptive immune system in the disease. The aim of this study was to investigate whether drug‐responsive T lymphocytes are detectable in patients who developed DILI with the combination, antimicrobial amoxicillin‐clavulanate.