Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor–induced epithelial‐mesenchymal transition

Zhi‐Chao Wang, Qiang Gao, Jie‐Yi Shi, Wei‐Jie Guo, Liu‐Xiao Yang, Xin‐Yang Liu, Long‐Zi Liu, Li‐Jie Ma, Meng Duan, Ying‐Jun Zhao, Yong‐Na Wu, Dong‐Mei Gao, Xiao‐Ying Wang, Guo‐Ming Shi, Zhen‐Bin Ding, Ai‐Wu Ke, Qi‐Qun Tang, Ya Cao, Jian Zhou, Jia Fan – 22 May 2015 – Hepatocellular carcinoma (HCC) is the third‐most lethal cancer worldwide. Understanding the molecular pathogenesis of HCC recurrence and metastasis is the key to improve patients’ prognosis.

Rejection triggers liver transplant tolerance: Involvement of mesenchyme‐mediated immune control mechanisms in mice

Miwa Morita, Daniel Joyce, Charles Miller, John J. Fung, Lina Lu, Shiguang Qian – 22 May 2015 – Liver tolerance was initially recognized by the spontaneous acceptance of liver allografts in many species. The underlying mechanisms are not completely understood. However, liver transplant (LT) tolerance absolutely requires interferon (IFN)‐γ, a rejection‐associated inflammatory cytokine.

Temoporfin improves efficacy of photodynamic therapy in advanced biliary tract carcinoma: A multicenter prospective phase II study

Andrej Wagner, Ulrike W. Denzer, Daniel Neureiter, Tobias Kiesslich, Andreas Puespoeck, Erik A.J. Rauws, Klaus Emmanuel, Nora Degenhardt, Ulrich Frick, Ulrich Beuers, Ansgar W. Lohse, Frieder Berr, Gernot W. Wolkersdörfer – 20 May 2015 – Photodynamic therapy using porfimer (P‐PDT) improves palliation and survival in nonresectable hilar bile duct cancer. Tumoricidal penetration depth of temoporfin‐PDT (T‐PDT) is twice that of P‐PDT. In a single‐arm phase II study we investigated the safety, efficacy, survival time, and adverse events of T‐PDT compared with previous data on P‐PDT.

Renal function improvement in liver transplant recipients after early everolimus conversion: A clinical practice cohort study in Spain

Itxarone Bilbao, Magdalena Salcedo, Miguel Angel Gómez, Carlos Jimenez, Javier Castroagudín, Joan Fabregat, Carolina Almohalla, Ignacio Herrero, Valentín Cuervas‐Mons, Alejandra Otero, Angel Rubín, Manuel Miras, Juan Rodrigo, Trinidad Serrano, Gonzalo Crespo, Manuel De la Mata, Javier Bustamante, M. Luisa Gonzalez‐Dieguez, Antonia Moreno, Isidoro Narvaez, Magda Guilera, for the EVEROLIVER study group – 19 May 2015 – A national, multicenter, retrospective study was conducted to assess the results obtained for liver transplant recipients with conversion to everolimus in daily practice.

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