Living donor liver transplantation for Echinococcus Alveolaris: single‐center experience

Fatih Ozdemir, Volkan Ince, Bora Barut, Asim Onur, Cuneyt Kayaalp, Sezai Yilmaz – 15 May 2015 – Echinococcus alveolaris (EA) causes a hepatic zoonotic infection and behaves like a malignant tumor during invasion. Liver transplantation (LT) is the only curative treatment option for this unresectable disease. Here, we share our experience with living donor liver transplantation (LDLT) due to EA from the time between March 2002 and November 2014 at the Liver Transplantation Institute of İnönü University.

Downstaging hepatocellular carcinoma: A systematic review and pooled analysis

Neehar D. Parikh, Akbar K. Waljee, Amit G. Singal – 15 May 2015 – Downstaging can facilitate liver transplantation (LT) for patients outside of Milan criteria with hepatocellular carcinoma (HCC); however, the optimal protocol and downstaging outcomes are poorly defined. We aimed to characterize rates of successful downstaging to within Milan criteria and post‐LT recurrence and survival among patients who underwent downstaging.

Long‐term safety of oral nucleos(t)ide analogs for patients with chronic hepatitis B: A cohort study of 53,500 subjects

Grace Lai‐Hung Wong, Yee‐Kit Tse, Vincent Wai‐Sun Wong, Terry Cheuk‐Fung Yip, Kelvin Kam‐Fai Tsoi, Henry Lik‐Yuen Chan – 14 May 2015 – Widespread and long‐term use of oral nucleos(t)ide analogs (NAs) to treat chronic hepatitis B (CHB) brings about safety data in a real‐life setting. We aimed to determine the risks of renal and bone side effects in patients receiving or who have received NAs as CHB treatment. A territory‐wide cohort study using the database from Hospital Authority, the major provider of medical services in Hong Kong, was conducted.

Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c‐jun amino‐terminal kinase activation and protein adduct formation

Nurdan Guldiken, Qin Zhou, Ozlem Kucukoglu, Melanie Rehm, Kateryna Levada, Annika Gross, Raymond Kwan, Laura P. James, Christian Trautwein, M. Bishr Omary, Pavel Strnad – 11 May 2015 – Keratins 8 and 18 (K8/K18) are the intermediate filaments proteins of simple‐type digestive epithelia and provide important cytoprotective function. K8/K18 variants predispose humans to chronic liver disease progression and poor outcomes in acute acetaminophen (APAP)‐related liver failure.

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