Javier Fernández, Puneeta Tandon, Jose Mensa, Guadalupe Garcia‐Tsao – 3 November 2015 – Patients with cirrhosis, particularly those with decompensated cirrhosis, are at increased risk of bacterial infections that may further precipitate other liver decompensations including acute‐on‐chronic liver failure. Infections constitute the main cause of death in patients with advanced cirrhosis, and strategies to prevent them are essential.
Patrick Starlinger, Stefanie Haegele, Florian Offensperger, Lukas Oehlberger, David Pereyra, Julia B Kral, Waltraud C. Schrottmaier, Sigrun Badrnya, Thomas Reiberger, Arnulf Ferlitsch, Judith Stift, Florian Luf, Christine Brostjan, Thomas Gruenberger, Alice Assinger – 3 November 2015 – Platelets promote liver regeneration through site‐specific serotonin release from dense granules, triggering proliferative signaling in hepatocytes.
Manuela Merli, Cristina Lucidi, Vincenza Di Gregorio, Barbara Lattanzi, Valerio Giannelli, Michela Giusto, Alessio Farcomeni, Giancarlo Ceccarelli, Marco Falcone, Oliviero Riggio, Mario Venditti – 3 November 2015 – Early diagnosis and appropriate treatment of infections in cirrhosis are crucial because of their high morbidity and mortality. Multidrug‐resistant (MDR) infections are on the increase in health care settings. Health‐care–associated (HCA) infections are still frequently treated as community‐acquired with a detrimental effect on survival.
Manuela Merli, Cristina Lucidi, Vincenza Di Gregorio, Barbara Lattanzi, Valerio Giannelli, Michela Giusto, Alessio Farcomeni, Giancarlo Ceccarelli, Marco Falcone, Oliviero Riggio, Mario Venditti – 3 November 2015 – Early diagnosis and appropriate treatment of infections in cirrhosis are crucial because of their high morbidity and mortality. Multidrug‐resistant (MDR) infections are on the increase in health care settings. Health‐care–associated (HCA) infections are still frequently treated as community‐acquired with a detrimental effect on survival.
Alexis P. Chidi, Shari Rogal, Cindy L. Bryce, Michael J. Fine, Chester B. Good, Larissa Myaskovsky, Vinod K. Rustgi, Allan Tsung, Kenneth J. Smith – 2 November 2015 – Recently approved, interferon‐free medication regimens for treating hepatitis C are highly effective, but extremely costly. We aimed to identify cost‐effective strategies for managing treatment‐naïve U.S. veterans with new hepatitis C medication regimens. We developed a Markov model with 1‐year cycle length for a cohort of 60‐year‐old veterans with untreated genotype 1 hepatitis C seeking treatment in a typical year.
Marta Cavallin, Salvatore Piano, Paolo Angeli – 2 November 2015
Giacomo Lanzoni, Vincenzo Cardinale, Guido Carpino – 2 November 2015 – Stem/progenitors for liver, biliary tree, and pancreas exist at early stages of development in the definitive ventral endoderm forming the foregut. In humans, they persist postnatally as part of a network, with evidence supporting their contributions to hepatic and pancreatic organogenesis throughout life. Multiple stem cell niches persist in specific anatomical locations within the human biliary tree and pancreatic ducts.
Abhinav Vasudevan, Zaid Ardalan, Paul Gow, Peter Angus, Adam Testro – 2 November 2015
Molly Jung, Mark H. Kuniholm, Gloria Y.F. Ho, Scott Cotler, Howard D. Strickler, Bharat Thyagarajan, Marston Youngblood, Robert C. Kaplan, Julia del Amo – 2 November 2015 – Little is known regarding the prevalence and distribution of hepatitis B virus (HBV) infection in U.S. Hispanics/Latinos. We sought to determine the prevalence of HBV exposure (serum HBV core antibody; anti‐HBc), active HBV infection (serum HBV surface antigen; HBsAg), and vaccine‐induced HBV immunity (antibody against HBV surface antigen; anti‐HBs) in U.S.
Robert S. Brown, Jacqueline G. O'Leary, K. Rajender Reddy, Alexander Kuo, Giuseppe J. Morelli, James R. Burton, R. Todd Stravitz, Christine Durand, Adrian M. Bisceglie, Paul Kwo, Catherine T. Frenette, Thomas G. Stewart, David R. Nelson, Michael W. Fried, Norah A. Terrault, on behalf of the Hepatitis C Therapeutic Registry Research Network Study Group – 31 October 2015 – Recurrent infection with the hepatitis C virus (HCV) after liver transplantation (LT) is associated with decreased graft and patient survival.