Declining liver graft quality threatens the future of liver transplantation in the United States

Eric S. Orman, Maria E. Mayorga, Stephanie B. Wheeler, Rachel M. Townsley, Hector H. Toro‐Diaz, Paul H. Hayashi, A. Sidney Barritt – 4 May 2015 – National liver transplantation (LT) volume has declined since 2006, in part because of worsening donor organ quality. Trends that degrade organ quality are expected to continue over the next 2 decades. We used the United Network for Organ Sharing (UNOS) database to inform a 20‐year discrete event simulation estimating LT volume from 2010 to 2030. Data to inform the model were obtained from deceased organ donors between 2000 and 2009.

Intracardiac thrombosis during liver transplant: A 17‐year single‐institution study

Prith Peiris, Sher‐Lu Pai, Stephen Aniskevich, Claudia C. Crawford, Klaus D. Torp, Beth L. Ladlie, Timothy S. Shine, C. Burcin Taner, Justin H. Nguyen – 4 May 2015 – Intracardiac thrombosis (ICT) during orthotopic liver transplantation (OLT) is an uncommon event. However, it is a devastating complication with high mortality when it occurs. This study aimed to identify possible predisposing factors for ICT during OLT. We retrospectively identified the cases of all patients with ICT during OLT at our institution from 1998 to 2014. Of 2750 OLTs performed, 10 patients had ICT intraoperatively.

The protective function of galectin‐9 in liver ischemia and reperfusion injury in mice

Hirofumi Hirao, Yoichiro Uchida, Kentaro Kadono, Hirokazu Tanaka, Toshiro Niki, Akira Yamauchi, Koichiro Hata, Takeshi Watanabe, Hiroaki Terajima, Shinji Uemoto – 30 April 2015 – Galectin‐9 (Gal‐9) has gained attention as a multifaceted player in adaptive and innate immunity. To elucidate the role of Gal‐9, we used a mouse model of partial liver ischemia/reperfusion injury (IRI) with wild type (WT) and Gal‐9 knockout (KO) mice as well as a recombinant galectin‐9 (reGal‐9) protein.

A computed tomography radiogenomic biomarker predicts microvascular invasion and clinical outcomes in hepatocellular carcinoma

Sudeep Banerjee, David S. Wang, Hyun J. Kim, Claude B. Sirlin, Michael G. Chan, Ronald L. Korn, Aaron M. Rutman, Surachate Siripongsakun, David Lu, Galym Imanbayev, Michael D. Kuo – 30 April 2015 – Microvascular invasion (MVI) in hepatocellular carcinoma (HCC) is an independent predictor of poor outcomes subsequent to surgical resection or liver transplantation (LT); however, MVI currently cannot be adequately determined preoperatively.

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