Prospective validation of ab initio liver transplantation in hepatocellular carcinoma upon detection of risk factors for recurrence after resection

Joana Ferrer‐Fàbrega, Alejandro Forner, Alexandre Liccioni, Rosa Miquel, Víctor Molina, Miquel Navasa, Constantino Fondevila, Juan Carlos García‐Valdecasas, Jordi Bruix, Josep Fuster – 13 November 2015 – A decade ago we proposed to enlist for transplantation those patients with resected hepatocellular carcinoma in whom pathology registered pejorative histological markers (microvascular invasion and/or satellites; ab initio indication) and not wait for the appearance of recurrence. This study evaluates the outcome of this approach.

Antiviral therapy in chronic hepatitis B viral infection during pregnancy: A systematic review and meta‐analysis

Robert S. Brown, Brian J. McMahon, Anna S.F. Lok, John B. Wong, Ahmed T. Ahmed, Mohamed A. Mouchli, Zhen Wang, Larry J. Prokop, Mohammad Hassan Murad, Khaled Mohammed – 13 November 2015 – Perinatal or mother‐to‐child transmission (MTCT) of hepatitis B virus (HBV) remains the major risk factor for chronic HBV infection worldwide. In addition to hepatitis B immune globulin and vaccination, oral antiviral therapies in highly viremic mothers can further decrease MTCT of HBV.

Reassessing the boundaries of liver transplantation for hepatocellular carcinoma: Where do we stand with tumor down‐staging?

Francis Y. Yao, Nicholas Fidelman – 11 November 2015 – Down‐staging of hepatocellular carcinoma prior to liver transplantation (LT) has generated a lot of interest in recent years and has been identified in two recent national conferences on hepatocellular carcinoma as one of the priorities for research. Down‐staging is defined as reduction in the tumor burden using local regional therapy specifically to meet acceptable criteria for LT.

Care delivery and outcomes among US veterans with hepatitis B: A national cohort study

Marina Serper, Gina Choi, Kimberly A. Forde, David E. Kaplan – 11 November 2015 – Previous studies have identified gaps in hepatitis B care. The objectives of this study were to evaluate the delivery of care among a national cohort of US veterans with chronic hepatitis B infection and examine risk factors for adverse clinical outcomes.

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