Effect of addition of statins to antiviral therapy in hepatitis C virus–infected persons: Results from ERCHIVES

Adeel A. Butt, Peng Yan, Hector Bonilla, Abdul‐Badi Abou‐Samra, Obaid S. Shaikh, Tracey G. Simon, Raymond T. Chung, Shari S. Rogal, for the ERCHIVES (Electronically Retrieved Cohort of HCV Infected Veterans) Study Team – 6 April 2015 – 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitors (statins) have been variably noted to affect hepatitis C virus (HCV) treatment response, fibrosis progression, and hepatocellular carcinoma (HCC) incidence, with some having a more potent effect than others.

Standard assessments of frailty are validated predictors of mortality in hospitalized patients with cirrhosis

Elliot B. Tapper, Daniel Finkelstein, Murray A. Mittleman, Gail Piatkowski, Michelle Lai – 4 April 2015 – The risk of morbidity and mortality for hospitalized patients with cirrhosis is high and incompletely captured by conventional indices. We sought to evaluate the predictive role of frailty in an observational cohort study of inpatients with decompensated cirrhosis between 2010 and 2013. The primary outcome was 90‐day mortality. Secondary outcomes included discharge to a rehabilitation hospital, 30‐day readmission, and length of stay.

High risk of delisting or death in liver transplant candidates following infections: Results from the North American consortium for the study of end‐stage liver disease

K. Rajender Reddy, Jacqueline G. O'Leary, Patrick S. Kamath, Michael B. Fallon, Scott W. Biggins, Florence Wong, Heather M. Patton, Guadalupe Garcia‐Tsao, Ram M. Subramanian, Leroy R. Thacker, Jasmohan S. Bajaj, for the North American Consortium for the Study of End‐Stage Liver Disease – 4 April 2015 – Because Model for End‐Stage Liver Disease (MELD) scores at the time of liver transplantation (LT) increase nationwide, patients are at an increased risk for delisting by becoming too sick or dying while awaiting transplantation.

The camKK2/camKIV relay is an essential regulator of hepatic cancer

Fumin Lin, Kathrina L. Marcelo, Kimal Rajapakshe, Cristian Coarfa, Adam Dean, Nathaniel Wilganowski, Holly Robinson, Eva Sevick, Karl‐Dimiter Bissig, Lauren C. Goldie, Anthony R. Means, Brian York – 4 April 2015 – Hepatic cancer is one of the most lethal cancers worldwide. Here, we report that the expression of Ca2+/calmodulin‐dependent protein kinase kinase 2 (CaMKK2) is significantly up‐regulated in hepatocellular carcinoma (HCC) and negatively correlated with HCC patient survival.

Subscribe to