The travails of setting up a living donor liver transplant program: Experience from Pakistan and lessons learned

Faisal Saud Dar, Abu Bakar Hafeez Bhatti, Abdul‐Wahab Dogar, Haseeb Zia, Sadaf Amin, Atif Rana, Rashid Nazer, Nasir Ayub Khan, Etizaz‐ud‐din Khan, Muhammad Zameer Rajput, Muhammad Salih, Najmul Hassan Shah – 17 April 2015 – Living donor liver transplantation (LDLT) is the only treatment option for patients with end‐stage liver disease (ESLD) where cadaveric donors are not available. In developing countries, the inception of LDLT programs remains a challenge. The first successful liver transplantation program in Pakistan started transplantation in 2012.

Cardiovascular disease after liver transplantation: When, What, and Who Is at Risk

Lynn A. Fussner, Julie K. Heimbach, Chun Fan, Ross Dierkhising, Elizabeth Coss, Michael D. Leise, Kymberly D. Watt – 16 April 2015 – The evolution of metabolic and cardiovascular disease (CVD) complications after liver transplantation (LT) is poorly characterized. We aim to illustrate the prevalence of obesity and metabolic syndrome (MS), define the cumulative incidence of CVD, and characterize risk factors associated with these comorbidities after LT. A retrospective review of 455 consecutive LT recipients from 1999 to 2004 with an 8‐ to 12‐year follow‐up was performed.

Clinical Course of acute‐on‐chronic liver failure syndrome and effects on prognosis

Thierry Gustot, Javier Fernandez, Elisabet Garcia, Filippo Morando, Paolo Caraceni, Carlo Alessandria, Wim Laleman, Jonel Trebicka, Laure Elkrief, Corinna Hopf, Pablo Solís‐Munoz, Faouzi Saliba, Stefan Zeuzem, Augustin Albillos, Daniel Benten, José Luis Montero‐Alvarez, Maria Teresa Chivas, Mar Concepción, Juan Córdoba, Aiden McCormick, Rudolf Stauber, Wolfgang Vogel, Andrea de Gottardi, Tania M.

Racial and ethnic disparities in access to and utilization of living donor liver transplants

Yael R. Nobel, Kimberly A. Forde, Linda Wood, Katarzyna Cartiera, Armando S. Munoz‐Abraham, Peter S. Yoo, Peter L. Abt, David S. Goldberg – 11 April 2015 – Living donor liver transplantation (LDLT) is a comparable alternative to deceased donor liver transplantation and can mitigate the risk of dying while waiting for transplant. Although evidence exists of decreased utilization of living donor kidney transplants among racial minorities, little is known about access to LDLT among racial/ethnic minorities.

Novel perspectives for hepatitis A virus therapy revealed by comparative analysis of hepatitis C virus and hepatitis A virus RNA replication

Katharina Esser‐Nobis, Christian Harak, Philipp Schult, Yuri Kusov, Volker Lohmann – 11 April 2015 – Hepatitis A virus (HAV) and hepatitis C virus (HCV) are two positive‐strand RNA viruses sharing a similar biology, but causing opposing infection outcomes, with HAV always being cleared and HCV establishing persistence in the majority of infections. To gain deeper insight into determinants of replication, persistence, and treatment, we established a homogenous cell‐culture model allowing a thorough comparison of RNA replication of both viruses.

Optimizing repeat liver transplant graft utility through strategic matching of donor and recipient characteristics

Kenneth Hung, Jane Gralla, Jennifer L. Dodge, Kiran M. Bambha, Melisa Dirchwolf, Hugo R. Rosen, Scott W. Biggins – 10 April 2015 – Repeat liver transplantation (LT) is controversial because of inferior outcomes versus primary LT. A minimum 1‐year expected post–re‐LT survival of 50% has been proposed. We aimed to identify combinations of Model for End‐Stage Liver Disease (MELD), donor risk index (DRI), and recipient characteristics achieving this graft survival threshold.

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